Evidence map›Paper›PMID 36901744›Full record

ArticleInternational journal of molecular sciences2023

Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage.

Takamasa Mizoguchi, Shohei Mikami, Mari Yatou, Yui Kondo, Shuhei Omaru, Shuhei Kuwabara, Wataru Okura, Syouta Noda, Takeshi Tenno, Hidekazu Hiroaki and 1 more

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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Current research of the Notch pathway in hepatocellular carcinoma.European journal of medical research · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takamasa MizoguchiGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.ORCID 0000-0002-9475-6495
Shohei MikamiGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Mari YatouGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Yui KondoGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Shuhei OmaruGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Shuhei KuwabaraGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Wataru OkuraGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Syouta NodaGraduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Aichi, Japan.
Takeshi TennoGraduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Aichi, Japan.
Hidekazu HiroakiGraduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Aichi, Japan.ORCID 0000-0003-1621-5893
Motoyuki ItohGraduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

Funding

Japan Society for the Promotion of Science 18H02568Japan Society for the Promotion of Science 19K06454Japan Society for the Promotion of Science 21H02621
6 · The paper itself

Abstract

BMP signaling is critical for many biological processes. Therefore, small molecules that modulate BMP signaling are useful for elucidating the function of BMP signaling and treating BMP signaling-related diseases. Here, we performed a phenotypic screening in zebrafish to examine the in vivo effects of N-substituted-2-amino-benzoic acid analogs NPL1010 and NPL3008 and found that they affect BMP signaling-dependent dorsal-ventral (D-V) patterning and bone formation in zebrafish embryos. Furthermore, NPL1010 and NPL3008 suppressed BMP signaling upstream of BMP receptors. BMP1 cleaves Chordin, an antagonist of BMP, and negatively regulates BMP signaling. Docking simulations demonstrated that NPL1010 and NPL3008 bind BMP1. We found that NPL1010 and NPL3008 partially rescued the disruptions in the D-V phenotype caused by

Indexed as

Bone Morphogenetic ProteinsZebrafishAnimalsAntigens, NeoplasmBody PatterningBone Morphogenetic Protein 1Carbonic Anhydrase IXGlycoproteinsIntercellular Signaling Peptides and ProteinsZebrafish ProteinsAntigens, NeoplasmBMP1a protein, zebrafishBone Morphogenetic Protein 1Bone Morphogenetic ProteinsCA9 protein, humanCarbonic Anhydrase IXchordinGlycoproteinsIntercellular Signaling Peptides and ProteinsZebrafish ProteinsBMP1BMP signalingchordinphenotype screeningsmall moleculezebrafish

Identifiers

PMID36901744
PMCPMC10001940

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.