ArticleInternational journal of environmental research and public health2023
Bidirectional Comorbid Associations between Back Pain and Major Depression in US Adults.
Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain-a multicenter pragmatic randomized controlled trial (RESET).Pain medicine (Malden, Mass.) · 2026Trial
- Mediators of the Pain-Depression Relationship in Adults with Chronic Pain: A Systematic Review and Exploratory Meta-Analyses.Journal of clinical medicine · 2026Review
- Barriers and facilitators to the delivery of rehabilitation in health systems by chiropractors: a SWOT analysis of perspectives from a world federation of chiropractic congress workshop.Chiropractic & manual therapies · 2026Article
- Observations from the RESET clinical trial: A post-hoc per protocol analysis of clinical outcomes with percutaneous 60-day medial branch PNS in chronic low back pain.Interventional pain medicine · 2026Article
- Pain and depression mediate the relationship between multimorbidity and frailty in older adults with diabetes.Scientific reports · 2026Article
- Sex Differences and Psychological Assessments in Chronic Pain: A Systematic Review and Meta-Analysis.Clinical neuropsychiatry · 2026Article
- Impact of Depression and Anxiety on Outcomes Following Muscle-Preserving Transforaminal Lumbar Interbody and Fusion.Cureus · 2026Article
- Depression among lumbar spine surgery patients: Uncovering the untold story.North American Spine Society journal · 2026Article
- [Whole-body cryotherapy for low back pain].Orthopadie (Heidelberg, Germany) · 2026Review
- Spinal Cord Stimulation as a Potential Therapeutic Modality for Managing Concurrent Chronic Low Back and Abdominal Pain Complicated by Device Migration: A Case Report.Clinical case reports · 2026Article
- A Comprehensive Mendelian Randomization Study of Bidirectional Causal Relationships Between Pain and Mental Disorders.Journal of pain research · 2026Article
- Timing of depressive episode onset relative to chronic pain reveals distinct patterns of affective and multisite pain.Frontiers in psychiatry · 2026Article
- Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses.Biological psychiatry global open science · 2025Article
- Development and validation of a risk prediction model for co-existing depression in middle-aged and older adults with low back pain.European journal of medical research · 2025Article
- Dynamic nomogram for predicting depression risk in middle-aged and older adults based on CHARLS.Scientific reports · 2025Article
- Asthma Hospitalizations in Children Before and After COVID-19: Insights from Northern Colombia.Clinics and practice · 2025Article
- Systemic Inflammation at the Crossroad of Major Depressive Disorder and Comorbidities: A Narrative Review.International journal of molecular sciences · 2025Review
- Management of low back pain among Medicaid beneficiaries: modalities, patterns, and perspectives across states.Health affairs scholar · 2025Article
- Article
- Genetics- and age-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice.Science advances · 2025Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low back pain and depression have been globally recognized as key public health problems and they are considered co-morbid conditions. This study explores both cross-sectional and longitudinal comorbid associations between back pain and major depression in the adult population in the United States. We used data from the Midlife in the United States survey (MIDUS), linking MIDUS II and III with a sample size of 2358. Logistic regression and Poisson regression models were used. The cross-sectional analysis showed significant associations between back pain and major depression. The longitudinal analysis indicated that back pain at baseline was prospectively associated with major depression at follow-up (PR 1.96, CI: 1.41, 2.74), controlling for health behavioral and demographic variables. Major depression at baseline was also prospectively associated with back pain at follow-up (PR 1.48, CI: 1.04, 2.13), controlling for a set of related confounders. These findings of a bidirectional comorbid association fill a gap in the current understanding of these comorbid conditions and could have clinical implications for the management and prevention of both depression and low back pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.