SynthesisInternational journal of environmental research and public health2023
Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.
Synthesis in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Ability of Chronic Pain Patients to Self-diagnose Their Chief Source of Low Back Pain
Comparison of the Effect of Pain Neuroscience Education Combined With Physiotherapy, and Physiotherapy Alone in Temporomandibular Disorders
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Effectiveness of Pain Neuroscience Education in Reducing Pain, Disability, Kinesiophobia, and Catastrophizing in Patients with Chronic Low Back Pain: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Risk-stratified Care Improves Pain-related Knowledge and Reduces Psychological Distress for Low Back Pain: A Secondary Analysis of a Randomized Trial.Clinical orthopaedics and related research · 2025Trial
- The effect of pain neuroscience education on chronic postsurgical pain after total knee arthroplasty: a randomized controlled trial.Acta orthopaedica · 2024Trial
- The Role of Behavioral and Psychological Interventions in Chronic Ocular Pain.Current pain and headache reports · 2026Review
- Research hotspots and emerging trends of pain neuroscience education in chronic pain management: A bibliometric visualization study.Medicine · 2026Article
- Effect of preoperative pain neuroscience education on pain catastrophizing and early recovery following upper extremity orthopaedic surgery: a randomized controlled trial.Irish journal of medical science · 2026Article
- Central Sensitization and Pain Catastrophizing Are More Strongly Associated with Health-Related Quality of Life than Bioelectrical Impedance Analysis-Derived Body-Composition Measures in Patients with Chronic Low Back Pain.Diagnostics (Basel, Switzerland) · 2026Article
- Beyond Structural Pathology: Central Sensitization and Chronic Pain with Reference to Lumbar Disc Herniation-A Narrative Review.Brain sciences · 2026Review
- Neuromuscular exercise combined with pain neuroscience education for knee osteoarthritis management in older women: protocol for a randomized controlled trial.Journal of orthopaedic surgery and research · 2026Article
- An exploration of possible future non-pharmacological multidisciplinary treatments to potentiate withdrawal strategy and recovery from medication overuse headache (MOH): a narrative review.Journal of oral & facial pain and headache · 2026Review
- Central sensitization as a predictor of short-term postoperative outcomes in lumbar spinal stenosis: a prospective observational study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Observational
- The Therapeutic Home Environment for Chronic Diseases: A Transdisciplinary Ecosystem for Achieving Migraine Freedom and Managing Comorbid Anxiety, Insomnia, and Chronic Pain.Healthcare (Basel, Switzerland) · 2026Article
- Pain neuroscience education for the management of chronic pain in elite volleyball players with chronic shoulder pain: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2026Article
- A Gamified Pain Management Intervention for Adults With Chronic Pain in Mainland China: Single-Arm Pre-Post Pilot Study With Machine Learning Predictive Modeling.JMIR formative research · 2026Article
- Heterogeneity of treatment effects in transcranial direct current stimulation for knee osteoarthritis pain and symptoms.Pain reports · 2026Article
- Acceptance of pain neuroscience education in chronic musculoskeletal pain conditions: qualitative systematic review.Pain reports · 2026Review
- Exploring pain conceptualization in relation to outcomes in patients with chronic low back pain: a prospective observational study.Croatian medical journal · 2026Observational
- Patient education for chronic musculoskeletal pain: a scoping review of recommendations, effectiveness, and educational content.Chiropractic & manual therapies · 2026Article
- The COMPASS framework for chronic pain and posttraumatic stress disorder: navigating the transition from threat to safety through yoga.Frontiers in public health · 2026Article
- Is There a Difference in Factors Affecting Rest Pain and Pain Intensity during Movement at 1 Year Post-total Knee Arthroplasty?Physical therapy research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo collect the available evidence about the effectiveness of pain neuroscience education (PNE) on pain, disability, and psychosocial factors in patients with chronic musculoskeletal (MSK) pain and central sensitization (CS).
methodsA systematic review was conducted. Searches were performed on Pubmed, PEDro, and CINAHL, and only randomized controlled trials (RCTs) enrolling patients ≥18 years of age with chronic MSK pain due to CS were included. No meta-analysis was conducted, and qualitative analysis was realized.
results15 RCTs were included. Findings were divided for diagnostic criteria (fibromyalgia-FM, chronic fatigue syndrome-CFS, low back pain-LBP, chronic spinal pain-CSP). PNE has been proposed as a single intervention or associated with other approaches, and different measures were used for the main outcomes considered. Conclusions, practice implication: PNE is effective in improving pain, disability, and psychosocial factors in patients with fibromyalgia, chronic low back pain (CLBP)-especially if associated with other therapeutic approaches-and also in patients with CFS and CSP. Overall, PNE seems to be more effective when proposed in one-to-one oral sessions and associated with reinforcement elements. However, specific eligibility criteria for chronic MSK pain due to CS are still lacking in most RCTs; therefore, for future research, it is mandatory to specify such criteria in primary studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.