ArticleFoods (Basel, Switzerland)2023
Validation of an LC-MS/MS Method for the Determination of Abscisic Acid Concentration in a Real-World Setting.
Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- MetScribeR: A Semiautomated Tool for Data Processing of In-House LC-MS Metabolite Reference Libraries.Journal of proteome research · 2025Article
- Metabolomic and antioxidant characterization of seven Egyptian and Saudi date syrups via GC-MS and UHPLC/MS with sensory bioactive insights.Scientific reports · 2025Article
- UPLC-HRMS-MS profiling of Ludwigia adscendens subsp. diffusa aerial parts and investigation of the anti-inflammatory effect.Scientific reports · 2025Article
- Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line.Antioxidants (Basel, Switzerland) · 2023Article
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Authors and funding
9 authors.
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Abstract
One of the most relevant aspects in evaluating the impact of natural bioactive compounds on human health is the assessment of their bioavailability. In this regard, abscisic acid (ABA) has attracted particular interest as a plant-derived molecule mainly involved in the regulation of plant physiology. Remarkably, ABA was also found in mammals as an endogenous hormone involved in the upstream control of glucose homeostasis, as evidenced by its increase after glucose load. The present work focused on the development and validation of a method for the determination of ABA in biological samples through liquid-liquid extraction (LLE), followed by liquid mass spectrometry (LC-MS) of the extract. To test method suitability, this optimized and validated method was applied to a pilot study on eight healthy volunteers' serum levels to evaluate ABA concentration after consumption of a standardized test meal (STM) and the administration of an ABA-rich nutraceutical product. The results obtained could meet the demands of clinical laboratories to determine the response to a glucose-containing meal in terms of ABA concentration. Interestingly, the detection of this endogenous hormone in such a real-world setting could represent a useful tool to investigate the occurrence of impaired ABA release in dysglycemic individuals and to monitor its eventual improvement in response to chronic nutraceutical supplementation.
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