Evidence map›Paper›PMID 36900405›Full record

ArticleCancers2023

First-Line Immunotherapy with Check-Point Inhibitors: Prospective Assessment of Cognitive Function.

Jamie S Myers, Adam C Parks, Jonathan D Mahnken, Kate J Young, Harsh B Pathak, Rajni V Puri, Amber Unrein, Phyllis Switzer, Yazan Abdulateef, Samantha Sullivan and 3 more

Open access · goldFull text read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function.Journal of experimental & clinical cancer research : CR · 2025
    Article
  4. Incidence and predictors of immune checkpoint inhibitor treatment-related cognitive impairment in a racial and ethnic diverse population.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  5. Unmasking a Paradox: Roles of the PD-1/PD-L1 Axis in Alzheimer's Disease-Associated Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jamie S MyersSchool of Nursing, University of Kansas, Kansas City, KS 66160, USA.ORCID 0000-0003-4582-9261
Adam C ParksDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jonathan D MahnkenDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Kate J YoungDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Harsh B PathakDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Rajni V PuriDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Amber UnreinUniversity of Kansas Alzheimer's Disease Research Center, Fairway, KS 66111, USA.
Phyllis SwitzerUniversity of Kansas Alzheimer's Disease Research Center, Fairway, KS 66111, USA.
Yazan AbdulateefDepartment of Quality Assurance, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Samantha SullivanUniversity of Kansas Alzheimer's Disease Research Center, Fairway, KS 66111, USA.
John F WalkerUniversity of Kansas Alzheimer's Disease Research Center, Fairway, KS 66111, USA.
David StreeterDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jeffrey M BurnsUniversity of Kansas Alzheimer's Disease Research Center, Fairway, KS 66111, USA.
University of Kansas Medical Center · USUniversity of Kansas · US

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

Approximately 40% of patients with cancer are eligible for check-point inhibitor (CPI) therapy. Little research has examined the potential cognitive impact of CPIs. First-line CPI therapy offers a unique research opportunity without chemotherapy-related confounders. The purpose of this prospective, observational pilot was to (1) demonstrate the feasibility of prospective recruitment, retention, and neurocognitive assessment for older adults receiving first-line CPI(s) and (2) provide preliminary evidence of changes in cognitive function associated with CPI(s). Patients receiving first-line CPI(s) (CPI Group) were assessed at baseline (

Indexed as

cancercheckpoint inhibitorscognitive functionfirst-line therapyimmunotherapy

Identifiers

PMID36900405
PMCPMC10000599
OpenAlexW4323313816

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read10
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.