Evidence map›Paper›PMID 36900389›Full record

ArticleCancers2023

CD22 Exon 12 Deletion as an Independent Predictor of Poor Treatment Outcomes in B-ALL.

Sanjive Qazi, Fatih M Uckun

Full text read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CD22 as a Target for Hematological Malignancies and Autoimmune Diseases.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sanjive QaziAres Pharmaceuticals, Saint Paul, MN 55110, USA.
Fatih M UckunAres Pharmaceuticals, Saint Paul, MN 55110, USA.ORCID 0000-0001-9334-183X

Funding

Targeting SYK Kinase in B-Lineage ALL with CD19-Specific C-61 NanoparticlesU01CA151837 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI UCKUN, FATIH M · 2010 to 2014
$2.3M
Targeting SYK Tyrosine Kinase to Overcome Radiation Resistance in ALLR01CA154471 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI UCKUN, FATIH M · 2011 to 2015
$1.6M
Amplifying Radiation Potency Against Leukemic Stem CellsR21CA164098 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI UCKUN, FATIH M · 2012 to 2013
$377k
NCI NIH HHS R01 CA154471NCI NIH HHS R01CA-154471NCI NIH HHS R21 CA164098NCI NIH HHS R21-CA-164098NCI NIH HHS U01 CA151837NCI NIH HHS U01-CA-151837
6 · The paper itself

Abstract

We previously reported a splicing defect (CD22ΔE12) associated with the deletion of exon 12 of the inhibitory co-receptor CD22 (Siglec-2) in leukemia cells from patients with CD19

Indexed as

aberrant splicingB-ALLCD22mRNArelapseSIGLEC-2

Identifiers

PMID36900389
PMCPMC10000517

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read98
identifiers read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.