Evidence map›Paper›PMID 36900344›Full record

ArticleCancers2023

Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia.

Ehsan Gharib, Parinaz Nasri Nasrabadi, Gilles A Robichaud

Full text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ehsan GharibDépartement de Chimie et Biochimie, Université de Moncton, Moncton, NB E1A 3E9, Canada.ORCID 0000-0001-6271-6731
Parinaz Nasri NasrabadiDépartement de Chimie et Biochimie, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Gilles A RobichaudDépartement de Chimie et Biochimie, Université de Moncton, Moncton, NB E1A 3E9, Canada.ORCID 0000-0002-5782-7899

Funding

Beatrice Hunter Cancer Research Institute 48156Canadian Cancer Society CHA-22Leukemia & Lymphoma Society of Canada 622763Mitacs IT21736Mitacs IT26716Natural Sciences and Engineering Research Council DDG-2020-00005New Brunswick Health Research Foundation 2020-LLSC-2006New Brunswick Innovation Foundation RAI-0000000251Vitalité Health Network DUO2022
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is a known hematologic malignancy associated with a growing incidence and post-treatment relapse. Hence, finding a reliable diagnostic biomarker for CLL is crucial. Circular RNAs (circRNAs) represent a new class of RNA involved in many biological processes and diseases. This study aimed to define a circRNA-based panel for the early diagnosis of CLL. To this point, the list of the most deregulated circRNAs in CLL cell models was retrieved using bioinformatic algorithms and applied to the verified CLL patients' online datasets as the training cohort (

Indexed as

cancerchronic lymphocytic leukemiacircular RNAdiagnosisdrug sensitivity predictionprognosis

Identifiers

PMID36900344
PMCPMC10000909

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read3
measurements read66
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.