Evidence map›Paper›PMID 36900294›Full record

ArticleCancers2023

Real-World Data on EGFR and ALK Testing and TKI Usage in Norway-A Nation-Wide Population Study.

Inger Johanne Zwicky Eide, Yngvar Nilssen, Elin Marie Stensland, Odd Terje Brustugun

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Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Inger Johanne Zwicky EideSection of Oncology, Drammen Hospital, Vestre Viken Hospital Trust, N-3004 Drammen, Norway.ORCID 0000-0003-1246-3048
Yngvar NilssenCancer Registry of Norway, N-0304 Oslo, Norway.
Elin Marie StenslandSection of Oncology, Drammen Hospital, Vestre Viken Hospital Trust, N-3004 Drammen, Norway.
Odd Terje BrustugunSection of Oncology, Drammen Hospital, Vestre Viken Hospital Trust, N-3004 Drammen, Norway.ORCID 0000-0002-5153-8391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies have shown the efficacy of EGFR- and ALK-directed therapies in non-small cell lung cancer (NSCLC). Real-world data on, e.g., testing patterns, uptake, and duration of treatment are scarce. Reflex EGFR and ALK testing of non-squamous NSCLCs were implemented in Norwegian guidelines in 2010 and 2013, respectively. We present a complete national registry data on incidence, pathology procedures, and drug prescription in the period of 2013 to 2020. Test rates for both EGFR and ALK increased over time and were 85% and 89%, respectively, at the end of the study period, independent of age up to 85 years. The positivity rate for EGFR was higher among females and young patients, whereas no sex difference was observed for ALK. EGFR-treated patients were older than ALK-treated patients (71 vs. 63 years at start,

Indexed as

ALKEGFRnon-small cell lung cancerpopulation-based studyregistrysurvival

Identifiers

PMID36900294
PMCPMC10001166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.