Evidence map›Paper›PMID 36900290›Full record

ArticleCancers2023

Pseudoprogression of Vestibular Schwannoma after Stereotactic Radiosurgery with Cyberknife

Daniel Rueß, Betina Schütz, Eren Celik, Christian Baues, Stephanie T Jünger, Volker Neuschmelting, Alexandra Hellerbach, Markus Eichner, Martin Kocher, Maximilian I Ruge

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In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  8. Review
  9. Article
  10. Article
  11. Radiotherapy for Growing Vestibular Schwannomas.JAMA otolaryngology-- head & neck surgery · 2025
    Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel RueßDepartment of Stereotaxy and Functional Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.ORCID 0000-0003-1811-5132
Betina SchützDepartment of Stereotaxy and Functional Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Eren CelikDepartment of Radiation Oncology, Cyberknife and Radiation Therapy, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Christian BauesDepartment of Radiation Oncology, Cyberknife and Radiation Therapy, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.ORCID 0000-0003-1733-6064
Stephanie T JüngerDepartment of General Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Volker NeuschmeltingDepartment of General Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Alexandra HellerbachDepartment of Stereotaxy and Functional Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Markus EichnerDepartment of Stereotaxy and Functional Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.
Martin KocherDepartment of Stereotaxy and Functional Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.ORCID 0000-0002-5674-9227
Maximilian I RugeDepartment of Stereotaxy and Functional Neurosurgery, Center of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Transient increase in volume of vestibular schwannomas (VS) after stereotactic radiosurgery (SRS) is common and complicates differentiation between treatment-related changes (pseudoprogression, PP) and tumor recurrence (progressive disease, PD). (2) Methods: Patients with unilateral VS (n = 63) underwent single fraction robotic-guided SRS. Volume changes were classified according to existing RANO criteria. A new response type, PP, with a >20% transient increase in volume was defined and divided into early (within the first 12 months) and late (>12 months) occurrence. (3) Results: The median age was 56 (range: 20-82) years, the median initial tumor volume was 1.5 (range: 0.1-8.6) cm

Indexed as

Cyberknife®radiosurgeryRANO criteriaskull base tumorsvestibular schwannoma

Identifiers

PMID36900290
PMCPMC10000564

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.