Evidence map›Paper›PMID 36900183›Full record

ArticleCancers2023

Dominant Gene Expression Profiles Define Adenoid Cystic Carcinoma (ACC) from Different Tissues: Validation of a Gene Signature Classifier for Poor Survival in Salivary Gland ACC.

Kathryn J Brayer, Huining Kang, Adel K El-Naggar, Simon Andreasen, Preben Homøe, Katalin Kiss, Lauge Mikkelsen, Steffen Heegaard, Daniel Pelaez, Acadia Moeyersoms and 4 more

Open access · goldFull text read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 13 citations in OpenAlex.

  1. Phase 2 Trial of Regorafenib in Recurrent/Metastatic Adenoid Cystic Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Trial
  2. Article
  3. Article
  4. Molecular pathology of adenoid cystic carcinoma.Histology and histopathology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. The evolving landscape of salivary gland tumors.CA: a cancer journal for clinicians
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Kathryn J BrayerDepartment of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Huining KangUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-4415-3573
Adel K El-NaggarDepartment of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-7175-9466
Simon AndreasenDepartment of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, 4600 Køge, Denmark.
Preben HomøeDepartment of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, 4600 Køge, Denmark.
Katalin KissDepartment of Pathology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark.
Lauge MikkelsenDepartment of Pathology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark.
Steffen HeegaardDepartment of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, 1165 Copenhagen, Denmark.ORCID 0000-0001-5906-7670
Daniel PelaezDr. Nasser Al-Rashid Orbital Vision Research Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-4483-5160
Acadia MoeyersomsDr. Nasser Al-Rashid Orbital Vision Research Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
David T TseDr. Nasser Al-Rashid Orbital Vision Research Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Yan GuoDepartment of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.ORCID 0000-0001-5252-3960
David Y LeeUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131, USA.
Scott A NessDepartment of Internal Medicine, Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.ORCID 0000-0001-6965-8909
University of New Mexico · USUniversity of Copenhagen · DKUniversity of Miami · USZealand University Hospital Køge · DKThe University of Texas MD Anderson Cancer Center · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Mutations and Target Genes in Adenoid Cystic CarcinomaR01DE023222 · NIDCR · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Viswanathan Palanisamy · 2012 to 2026
$5.6M
TRANSFORMING FUNCTIONS OF THE V-MYB ONCOGENE PRODUCTR01CA058443 · NCI · UNIVERSITY OF NEW MEXICO · PI NESS, SCOTT A. · 1995 to 2010
$2.6M
Alternative RNA splicing and protein products in leukemia outcome (PQ11)R01CA170250 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI NESS, SCOTT A. · 2012 to 2015
$2.3M
Myb protein specificity in human hematopoietic cellsR01CA105257 · NCI · UNIVERSITY OF NEW MEXICO · PI NESS, SCOTT A. · 2005 to 2009
$1.3M
Lab Automation for a Genomics Shared ResourcesR24OD035446 · OD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI NESS, SCOTT A. · 2023 to 2023
$68k
NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA058443NCI NIH HHS R01 CA105257NCI NIH HHS R01 CA170250NIDCR NIH HHS R01 DE023222NIH HHS R24 OD035446
6 · The paper itself

Abstract

Adenoid cystic carcinoma (ACC) is an aggressive malignancy that most often arises in salivary or lacrimal glands but can also occur in other tissues. We used optimized RNA-sequencing to analyze the transcriptomes of 113 ACC tumor samples from salivary gland, lacrimal gland, breast or skin. ACC tumors from different organs displayed remarkedly similar transcription profiles, and most harbored translocations in the

Indexed as

bioinformaticsbiomarkerMYB oncogeneoral cancersurvival analysistranscriptome analysis

Identifiers

PMID36900183
PMCPMC10000625
OpenAlexW4321600115

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read12
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.