Evidence map›Paper›PMID 36900166›Full record

ArticleCancers2023

Is Segmental Ureterectomy Associated with Inferior Survival for Localized Upper-Tract Urothelial Carcinoma of the Ureter Compared to Radical Nephroureterectomy?

Marco Paciotti, Khalid Y Alkhatib, David-Dan Nguyen, Kendrick Yim, Stuart R Lipsitz, Matthew Mossanen, Paolo Casale, Phillip M Pierorazio, Adam S Kibel, Quoc-Dien Trinh and 3 more

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In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marco PaciottiCenter for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.
Khalid Y AlkhatibCenter for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.ORCID 0000-0002-6008-0503
David-Dan NguyenCenter for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.
Kendrick YimDivision of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Stuart R LipsitzCenter for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.
Matthew MossanenDivision of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Paolo CasaleDepartment of Urology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Phillip M PierorazioDivision of Urology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Adam S KibelDivision of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Quoc-Dien TrinhCenter for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.
Nicoló Maria BuffiDepartment of Urology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Giovanni LughezzaniDepartment of Urology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Alexander P ColeCenter for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Segmental ureterectomy (SU) is an alternative to radical nephroureterectomy (RNU) in the treatment of upper-tract urothelial carcinoma (UTUC) of the ureter. SU generally preserves renal function, at the expense of less intensive cancer control. We aim to assess whether SU is associated with inferior survival compared to RNU. Using the National Cancer Database (NCDB), we identified patients diagnosed with localized UTUC of the ureter between 2004-2015. We used a propensity-score-overlap-weighted (PSOW) multivariable survival model to compare survival following SU vs. RNU. PSOW-adjusted Kaplan-Meier curves were generated and we performed a non-inferiority test of overall survival. A population of 13,061 individuals with UTUC of the ureter receiving either SU or RNU was identified; of these, 9016 underwent RNU and 4045 SU. Factors associated with decreased likelihood of receiving SU were female gender (OR, 0.81; 95% CI, 0.75-0.88;

Indexed as

comparative effectivenessnephroureterectomysegmental ureterectomyupper-tract urothelial carcinomaureter cancer

Identifiers

PMID36900166
PMCPMC10000204

What OpenQuestion holds

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LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.