Evidence map›Paper›PMID 36900157›Full record

ArticleCancers2023

Declined Organs for Liver Transplantation: A Right Decision or a Missed Opportunity for Patients with Hepatocellular Carcinoma?

Vladimir J Lozanovski, Said Adigozalov, Elias Khajeh, Omid Ghamarnejad, Ehsan Aminizadeh, Christina Schleicher, Thilo Hackert, Beat Peter Müller-Stich, Uta Merle, Susanne Picardi and 6 more

Full text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Vladimir J LozanovskiDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-7332-3973
Said AdigozalovDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Elias KhajehDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Omid GhamarnejadDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0001-7424-1323
Ehsan AminizadehDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Christina SchleicherGerman Organ Procurement Organization (Deutsche Stiftung Organtransplantation, DSO), 60594 Frankfurt, Germany.
Thilo HackertDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Beat Peter Müller-StichDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Uta MerleDepartment of Internal Medicine IV, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1386-3350
Susanne PicardiDepartment of Anesthesiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Frederike LundDepartment of Anesthesiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-2260-146X
De-Hua ChangLiver Cancer Center Heidelberg, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Markus MiethDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Hamidreza FonouniDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Mohammad GolrizDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-7184-1507
Arianeb MehrabiDepartment of General, Visceral and Transplant Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplantation is the only promising treatment for end-stage liver disease and patients with hepatocellular carcinoma. However, too many organs are rejected for transplantation.

methodsWe analyzed the factors involved in organ allocation in our transplant center and reviewed all livers that were declined for transplantation. Reasons for declining organs for transplantation were categorized as major extended donor criteria (maEDC), size mismatch and vascular problems, medical reasons and risk of disease transmission, and other reasons. The fate of the declined organs was analyzed.

results1086 declined organs were offered 1200 times. A total of 31% of the livers were declined because of maEDC, 35.5% because of size mismatch and vascular problems, 15.8% because of medical reasons and risk of disease transmission, and 20.7% because of other reasons. A total of 40% of the declined organs were allocated and transplanted. A total of 50% of the organs were completely discarded, and significantly more of these grafts had maEDC than grafts that were eventually allocated (37.5% vs. 17.7%,

conclusionMost organs were declined because of poor organ quality. Donor-recipient matching at time of allocation and organ preservation must be improved by allocating maEDC grafts using individualized algorithms that avoid high-risk donor-recipient combinations and unnecessary organ declination.

Indexed as

declined organsEurotransplantextended donor criteriaextended right lobe liver transplantationHCChepatocellular carcinomaliver transplantationMELD

Identifiers

PMID36900157
PMCPMC10000136

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read61
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.