Evidence map›Paper›PMID 36900136›Full record

ReviewDiagnostics (Basel, Switzerland)2023

More than Just Skin-Deep: A Review of Imaging's Role in Guiding CAR T-Cell Therapy for Advanced Melanoma.

Conor M Prendergast, Kathleen M Capaccione, Egesta Lopci, Jeeban P Das, Alexander N Shoushtari, Randy Yeh, Daniel Amin, Laurent Dercle, Dorine De Jong

Open access · goldFull text readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Conor M PrendergastDepartment of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Kathleen M CapaccioneDepartment of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6536-2673
Egesta LopciDepartment of Nuclear Medicine, IRCSS Humanitas Research Hospital, 20089 Milan, Italy.ORCID 0000-0001-9732-1094
Jeeban P DasMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Alexander N ShoushtariMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-8065-4412
Randy YehMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Daniel AminDepartment of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Laurent DercleDepartment of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Dorine De JongMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-4366-9145
Columbia University Irving Medical Center · USMemorial Sloan Kettering Cancer Center · USIRCCS Humanitas Research Hospital · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Advanced melanoma is one of the deadliest cancers, owing to its invasiveness and its propensity to develop resistance to therapy. Surgery remains the first-line treatment for early-stage tumors but is often not an option for advanced-stage melanoma. Chemotherapy carries a poor prognosis, and despite advances in targeted therapy, the cancer can develop resistance. CAR T-cell therapy has demonstrated great success against hematological cancers, and clinical trials are deploying it against advanced melanoma. Though melanoma remains a challenging disease to treat, radiology will play an increasing role in monitoring both the CAR T-cells and response to therapy. We review the current imaging techniques for advanced melanoma, as well as novel PET tracers and radiomics, in order to guide CAR T-cell therapy and manage potential adverse events.

Indexed as

CAR T-cellCAR T-cell imagingCAR T-cell toxicitymelanomametastasesPET radiotracersradiologyradiomics

Identifiers

PMID36900136
PMCPMC10000712
OpenAlexW4323312256

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read32
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.