Evidence map›Paper›PMID 36900105›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Validation of an Automated System for the Extraction of a Wide Dataset for Clinical Studies Aimed at Improving the Early Diagnosis of Candidemia.

Daniele Roberto Giacobbe, Sara Mora, Alessio Signori, Chiara Russo, Giorgia Brucci, Cristina Campi, Sabrina Guastavino, Cristina Marelli, Alessandro Limongelli, Antonio Vena and 5 more

Full text read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Deep Learning for the Early Diagnosis of Candidemia.Infectious diseases and therapy · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Daniele Roberto GiacobbeDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-2385-1759
Sara MoraDepartment of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16145 Genoa, Italy.ORCID 0000-0002-0613-3248
Alessio SignoriSection of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-6289-9144
Chiara RussoDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.
Giorgia BrucciDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.
Cristina CampiDepartment of Mathematics (DIMA), University of Genoa, 16146 Genoa, Italy.ORCID 0000-0003-2105-8554
Sabrina GuastavinoDepartment of Mathematics (DIMA), University of Genoa, 16146 Genoa, Italy.
Cristina MarelliClinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0003-1510-1819
Alessandro LimongelliDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-7995-5528
Antonio VenaDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-0697-3992
Malgorzata MikulskaDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-5535-4602
Anna MarcheseDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy.
Antonio Di BiagioDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-1436-5089
Mauro GiacominiDepartment of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16145 Genoa, Italy.ORCID 0000-0001-5646-2034
Matteo BassettiDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.

Funding

Pfizer Global Medical Grants (GMG) for general research Project Tracking Number 69511763
6 · The paper itself

Abstract

There is increasing interest in assessing whether machine learning (ML) techniques could further improve the early diagnosis of candidemia among patients with a consistent clinical picture. The objective of the present study is to validate the accuracy of a system for the automated extraction from a hospital laboratory software of a large number of features from candidemia and/or bacteremia episodes as the first phase of the AUTO-CAND project. The manual validation was performed on a representative and randomly extracted subset of episodes of candidemia and/or bacteremia. The manual validation of the random extraction of 381 episodes of candidemia and/or bacteremia, with automated organization in structured features of laboratory and microbiological data resulted in ≥99% correct extractions (with confidence interval < ±1%) for all variables. The final automatically extracted dataset consisted of 1338 episodes of candidemia (8%), 14,112 episodes of bacteremia (90%), and 302 episodes of mixed candidemia/bacteremia (2%). The final dataset will serve to assess the performance of different ML models for the early diagnosis of candidemia in the second phase of the AUTO-CAND project.

Indexed as

bloodstream infectionsCandidaearly diagnosismachine learningrelational database

Identifiers

PMID36900105
PMCPMC10001256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.