Evidence map›Paper›PMID 36900005›Full record

ReviewDiagnostics (Basel, Switzerland)2023

Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin's Lymphoma.

Abdullah Alfaifi, Mohammed Y Refai, Mohammed Alsaadi, Salem Bahashwan, Hafiz Malhan, Waiel Al-Kahiry, Enas Dammag, Ageel Ageel, Amjed Mahzary, Raed Albiheyri and 2 more

Full text readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. The role ofFrontiers in oncology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdullah AlfaifiDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0747-9451
Mohammed Y RefaiDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia.ORCID 0000-0002-6590-5594
Mohammed AlsaadiDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-2976-2696
Salem BahashwanHematology Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Hafiz MalhanPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia.ORCID 0000-0002-7148-9769
Waiel Al-KahiryPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia.
Enas DammagPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia.
Ageel AgeelPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia.ORCID 0000-0002-3058-1366
Amjed MahzaryEradah Hospital, Ministry of Health, Jazan 82943, Saudi Arabia.
Raed AlbiheyriDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9739-5496
Hussein AlmehdarDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ishtiaq QadriDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-4334-0585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin's lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliberated as successful and restorative. Therefore, better protective action is needed to improve the condition of those patients who are extensively affected by cancer when diagnosed for the first time. The development of new and efficient methods for early detection of cancer has become crucial nowadays. Biomarkers are urgently needed for diagnosing B-cell non-Hodgkin's lymphoma and assessing the severity of the disease and its prognosis. New possibilities are now open for diagnosing cancer with the help of metabolomics. The study of all the metabolites synthesised in the human body is called "metabolomics." A patient's phenotype is directly linked with metabolomics, which can help in providing some clinically beneficial biomarkers and is applied in the diagnostics of B-cell non-Hodgkin's lymphoma. In cancer research, it can analyse the cancerous metabolome to identify the metabolic biomarkers. This review provides an understanding of B-cell non-Hodgkin's lymphoma metabolism and its applications in medical diagnostics. A description of the workflow based on metabolomics is also provided, along with the benefits and drawbacks of various techniques. The use of predictive metabolic biomarkers for the diagnosis and prognosis of B-cell non-Hodgkin's lymphoma is also explored. Thus, we can say that abnormalities related to metabolic processes can occur in a vast range of B-cell non-Hodgkin's lymphomas. The metabolic biomarkers could only be discovered and identified as innovative therapeutic objects if we explored and researched them. In the near future, the innovations involving metabolomics could prove fruitful for predicting outcomes and bringing out novel remedial approaches.

Indexed as

B-cell non-Hodgkin’s lymphomabiomarkersearly diagnosismetabolitesmetabolomicstherapeutic

Identifiers

PMID36900005
PMCPMC10000528

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.