Evidence map›Paper›PMID 36899866›Full record

ArticleCells2023

CRISPR/dCas9-KRAB-Mediated Suppression of

Samrat Roy Choudhury, Billie Heflin, Erin Taylor, Brian Koss, Nathan L Avaritt, Alan J Tackett

Open access · goldFull text read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Epigenetic editing of marine medaka (Zoological research · 2026
    Article
  2. Article
  3. Article
  4. Screening and Identification of Hnf1ba-International journal of molecular sciences · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Samrat Roy ChoudhuryPediatric Hematology-Oncology, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.ORCID 0000-0002-6555-3031
Billie HeflinDepartment of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Erin TaylorDepartment of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Brian KossDepartment of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Nathan L AvarittDepartment of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Alan J TackettDepartment of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · US

Funding

Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Joseph Lee Alge · 2017 to 2026
$27.6M
Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironmentDP5OD031863 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI KOSS, BRIAN · 2021 to 2025
$1.9M
Identification of Druggable Targets to Complement Melanoma TherapyR01CA236209 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI TACKETT, ALAN · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA236209NIGMS NIH HHS P20 GM121293NIH HHS DP5 OD031863
6 · The paper itself

Abstract

Overexpression of S100B is routinely used for disease-staging and for determining prognostic outcomes in patients with malignant melanoma. Intracellular interactions between S100B and wild-type (WT)-p53 have been demonstrated to limit the availability of free WT-p53 in tumor cells, inhibiting the apoptotic signaling cascade. Herein, we demonstrate that, while oncogenic overexpression of

Indexed as

MelanomaTumor Suppressor Protein p53AnimalsApoptosisHumansMicePromoter Regions, GeneticS100 Calcium Binding Protein beta SubunitTranscription FactorsS100B protein, humanS100b protein, mouseS100 Calcium Binding Protein beta SubunitTranscription FactorsTumor Suppressor Protein p53apoptosiscell deathCRISPRdCas9-KRABmelanomaS100b

Identifiers

PMID36899866
PMCPMC10000373
OpenAlexW4322500994

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read46
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.