Evidence map›Paper›PMID 36899465›Full record

ArticleTissue barriers2024

Genital epithelial barrier function is conserved by intravaginal rings releasing etonogestrel and ethinyl estradiol.

Mohan Liu, Rodolfo D Vicetti Miguel, Nirk E Quispe Calla, Kristen M Aceves, Linda Fritts, Christopher J Miller, John A Moss, Marc M Baum, Thomas L Cherpes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue barriers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Mohan LiuDepartment of Otolaryngology - Head and Neck Surgery, The Ohio State University (OSU) College of Medicine, Columbus, OH, USA.
Rodolfo D Vicetti MiguelDepartment of Otolaryngology - Head and Neck Surgery, The Ohio State University (OSU) College of Medicine, Columbus, OH, USA.
Nirk E Quispe CallaDepartment of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Kristen M AcevesCollege of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA.
Linda FrittsCalifornia National Primate Research Center, University of California, Davis, Davis, CA, USA.
Christopher J MillerCalifornia National Primate Research Center, University of California, Davis, Davis, CA, USA.
John A MossDepartment of Chemistry, Oak Crest Institute of Science, Monrovia, CA, USA.
Marc M BaumDepartment of Chemistry, Oak Crest Institute of Science, Monrovia, CA, USA.
Thomas L CherpesDepartment of Otolaryngology - Head and Neck Surgery, The Ohio State University (OSU) College of Medicine, Columbus, OH, USA.
The Ohio State University · USOak Crest Institute of Science · USUniversity of California, Davis · USStanford University · USWestern University of Health Sciences · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Estrogen reverses progestin-mediated loss of genital mucosal barrier functionR01HD094634 · NICHD · STANFORD UNIVERSITY · PI CHERPES, THOMAS L. · 2018 to 2022
$4.0M
NICHD NIH HHS R01 HD094634NIH HHS P51 OD011107
6 · The paper itself

Abstract

The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring NuvaRing® is another contraceptive option that like DMPA suppresses hypothalamic pituitary ovarian (HPO) axis function with local release of progestin (etonogestrel) and estrogen (ethinyl estradiol). As we previously reported that treating mice with DMPA and estrogen averts the loss of genital epithelial integrity and barrier function induced by DMPA alone, in the current investigation we compared genital levels of the cell-cell adhesion molecule desmoglein-1 (DSG1) and genital epithelial permeability in rhesus macaques (RM) treated with DMPA or a NuvaRing®re-sized for RM (N-IVR). While these studies demonstrated comparable inhibition of the HPO axis with DMPA or N-IVR, DMPA induced significantly lower genital DSG1 levels and greater tissue permeability to intravaginally administered low molecular mass molecules. By identifying greater compromise of genital epithelial integrity and barrier function in RM administered DMPA vs. N-IVR, our results add to the growing body of evidence that indicate DMPA weakens a fundamental mechanism of anti-pathogen host defense in the female genital tract.

Indexed as

Contraceptive Agents, FemaleDesogestrelMedroxyprogesterone AcetateAnimalsEstrogensEthinyl EstradiolFemaleGenitaliaHumansMacaca mulattaMiceProgestinsContraceptive Agents, FemaleDesogestrelEstrogensEthinyl EstradioletonogestrelMedroxyprogesterone AcetateProgestinsDepot-medroxyprogesterone acetatedesmoglein-1epithelial barrier functionepithelial integrityNuvaRing®rhesus macaque

Identifiers

PMID36899465
PMCPMC10832912
OpenAlexW4323920658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.