Association between very advanced maternal age women with gestational diabetes mellitus and the risks of adverse infant outcomes: a cohort study from the NVSS 2014-2019.

Lin Lu, Lidan He, Jifen Hu, Jianhua Li

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Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed

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5 citing papers in PubMed.

Effect of advanced maternal age on the risk of adverse birth outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2025
Article
Gestational Diabetes Mellitus: The Dual Risk of Small and Large for Gestational Age: A Narrative Review.Medical sciences (Basel, Switzerland) · 2025
Review
The impact of gestational diabetes mellitus on maternal-fetal pregnancy outcomes and fetal growth: a multicenter longitudinal cohort study.Frontiers in pediatrics · 2025
Article
Research Progress and Clinical Implications of Generative Artificial Intelligence in Perinatal Health Care for Advanced Maternal Age Pregnant Women.International journal of women's health · 2025
Review
The association between maternal diabetes and neonatal seizures: a nested case-Control study.Frontiers in pediatrics · 2023
Article

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4 authors.

Lin LuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, China.

Lidan HeDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, China.

Jifen HuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, China.

Jianhua LiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, China. johnli2002@outlook.com.

Funding

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6 · The paper itself

Abstract

backgroundTo evaluate the association between gestational diabetes mellitus (GDM) and infant outcomes in women of very advanced maternal age (vAMA) (≥45 years).

methodsThis cohort study utilized data from the National Vital Statistics System (NVSS) database (2014-2019) in the United States. Preterm birth was the primary outcome, which was subdivided into extremely preterm, very preterm, and moderate or late preterm. The secondary outcomes were neonatal intensive care unit (NICU) admission, low birthweight and small for gestational age. Univariate and multivariate logistic regression analyses were used to explore the association between GDM and infant outcomes among vAMA women. Subgroup analyses were performed based on race and use of infertility treatment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated.

resultsA total of 52,544 vAMA pregnant women were included. All analysis made comparisons between women with vAMA and GDM and women with vAMA and no GDM. Women with GDM had a significantly higher risk of preterm birth than those without GDM (OR = 1.26, 95%CI = 1.18-1.36, P < 0.001). Compared with women without GDM, those with GDM had a significantly increased risk of moderate or late preterm birth (OR = 1.27, 95%CI = 1.18-1.37, P < 0.001); no significant association of GDM with extremely preterm birth and very preterm birth was observed. Women with GDM had a significantly greater risk of NICU admission than those without (OR = 1.33, 95%CI = 1.23-1.43, P < 0.001). GDM was associated with a significantly lower risk of low birthweight (OR = 0.91, 95%CI = 0.84-0.98, P = 0.010), and no significant association was found between GDM and small for gestational age (OR = 0.95, 95%CI = 0.87-1.03, P = 0.200) in vAMA women.

conclusionvAMA women with GDM had an increased risk of preterm birth, especially moderate or late preterm birth. NICU admission and low birthweight were also associated with GDM among vAMA women.

Indexed as

Diabetes, GestationalPremature BirthBirth WeightCohort StudiesFemaleFetal Growth RetardationHumansInfantInfant, NewbornMaternal AgeMiddle AgedPregnancyPregnancy OutcomeGestational diabetes mellitusInfant outcomesNVSSPremature birthVery advanced maternal age

Identifiers

PMID36899316

DOI10.1186/s12884-023-05449-0

PMCPMC9999489

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