Evidence map›Paper›PMID 36899207›Full record

ArticleBulletin of experimental biology and medicine2023

Differences in the Differentiation Potential and Relative Levels of Gene Expression in the Bone Marrow-Derived Fibroblast Colony-Forming Units in Patients during the Onset of Aplastic Anemia Depending on the Disease Severity.

A I Dorofeeva, I N Shipunova, A V Luchkin, A V Abramova, Z T Fidarova, V N Dvirnyk, I V Galtseva, E A Mikhailova, E N Parovichnikova

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Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

A I DorofeevaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
I N ShipunovaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia. iranifontova@yandex.ru.
A V LuchkinNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
A V AbramovaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
Z T FidarovaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
V N DvirnykNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
I V GaltsevaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
E A MikhailovaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
E N ParovichnikovaNational Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
National Medical Research Center of Cardiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The differentiation potential of individual clones of fibroblast CFU (CFU-F) was studied and the relative expression level of genes was analyzed in the culture of CFU-F from the bone marrow in patients with non-severe and severe forms of aplastic anemia at the onset of the disease. The differentiation potential of CFU-F clones was determined by the relative expression of marker genes using quantitative PCR. In aplastic anemia, the ratio of CFU-F clones with different differentiation potential changes, but the molecular mechanisms of this phenomenon are different in non-severe and severe aplastic anemia. In the culture of CFU-F in non-severe and severe aplastic anemia, the relative expression level of genes associated with the maintenance of the hematopoietic stem cell in the bone marrow niche changes, but the decrease in the expression of immunoregulatory genes occurs in severe form only, which may reflect differences in the pathogenesis of non-severe and severe aplastic anemia.

Indexed as

Anemia, AplasticBone MarrowCell DifferentiationCells, CulturedColony-Forming Units AssayFibroblastsGene ExpressionHematopoietic Stem CellsHumansPatient Acuityaplastic anemiacolony-forming units of fibroblastdifferentiation potentialgene expressionhematopoietic microenvironment

Identifiers

PMID36899207
OpenAlexW4323921360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.