SynthesisMolecular psychiatry2023
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Equity and Cancer Survival Among Veterans Health Administration Patients: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Childhood Environmental Exposures and Adult Disease.Pediatric pulmonology · 2026Review
- Acute stress induces changes in epigenome-wide DNA methylation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cord blood DNA methylation and cell-type composition are not significantly associated with severe preeclampsia after cell-type and clinical covariate adjustment.GigaScience · 2026Article
- The brain-gut axis in autism spectrum disorder: from gastrointestinal dysfunction to neuroimmune mechanisms.Frontiers in psychiatry · 2026Review
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Early Life Stress Effects on Children's Biology, Behavior, and Health: Evidence, Mediators, Moderators, and Solutions.Annual review of psychology · 2026Review
- Adversity, adiposity, nutrition and metabolic well-being in multi-ethnic Asia.Nature metabolism · 2026Review
- RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood.Genome biology · 2025Article
- Interactive effects of genotype with prenatal stress on DNA methylation at birth.Molecular psychiatry · 2025Article
- Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity.Nature metabolism · 2025Article
- Parental major life events before or during pregnancy and autistic behaviors among preschool children.Scientific reports · 2025Article
- A Changepoint Detection-Based General Methodology for Robust Signal Processing: An Application to Understand Preeclampsia's Mechanisms.Bioengineering (Basel, Switzerland) · 2025Article
- Maternal Social Determinants of Health and Risk of Perinatal Hypoxic-Ischemic Encephalopathy.JAMA neurology · 2025Article
- Cell type proportions rather than DNA methylation in the cord blood show significant associations with severe preeclampsia.medRxiv : the preprint server for health sciences · 2025Article
- Mediation of DNA methylation (cg04622888 and cg05037505) in the association between childhood maltreatment and non-suicidal self-injury in early adolescents.European child & adolescent psychiatry · 2025Article
- Improving Cardiovascular Health Through the Consideration of Social Factors in Genetics and Genomics Research: A Scientific Statement From the American Heart Association.Circulation. Cardiovascular quality and outcomes · 2025Review
- Postpartum Maternal Stress is Unrelated to the Infant Fecal Microbiome, but is Associated With the Human Milk Microbiome in Exclusively Breastfeeding Mother-Infant Dyads: The Mother-Infant Microbiomes, Behavior, and Ecology Study (MIMBES).American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Associations between maternal adversity and health and children's telomere length.Translational psychiatry · 2025Article
- Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 17 institutions in 7 countries.
Anna Kotsakis Ruehlmann *University of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA.ORCID 0000-0002-0440-1384
Sara Sammallahti *Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.
Andrea P Cortés HidalgoErasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.
Kelly M BakulskiUniversity of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA.
Elisabeth B BinderMax Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.ORCID 0000-0001-7088-6618
Megan Loraine CampbellUniversity of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.
Doretta CaramaschiSchool of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Charlotte A M CecilErasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.
Elena ColicinoDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cristiana CruceanuMax Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
Darina CzamaraMax Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.ORCID 0000-0001-7381-904X
Linda DieckmannMax Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
John DouUniversity of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.ORCID 0000-0002-9801-5774
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0003-4867-9465
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Gunda HerberthHelmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.ORCID 0000-0003-0212-3509
Thanh T HoangEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, USA.
Lotte C HoutepenMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
Anke HülsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6005-417X
Nastassja KoenDepartment of Psychiatry and Mental Health, University of Cape Town, South Africa; and UCT Neuroscience Institute, Cape Town, South Africa.ORCID 0000-0002-1119-8142
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, USA.ORCID 0000-0003-4911-5290
Maria C MagnusNorwegian Institute of Public Health, Centre for Fertility and Health, Oslo, Norway.
Giulia MancanoMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
Rosa H MulderThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Katri RäikkönenUniversity of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland.
Stefan RöderHelmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
Rebecca J SchmidtUniversity of California-Davis, School of Medicine, Department of Public Health Sciences, Davis, CA, USA.ORCID 0000-0003-1582-2747
Tabea S SendDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gemma SharpSchool of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.ORCID 0000-0003-2906-4035
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, South Africa; and UCT Neuroscience Institute, Cape Town, South Africa.ORCID 0000-0001-7218-7810
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0003-1080-4339
Johanna TuhkanenUniversity of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-1571-1468
Heather J ZarDepartment of Paediatrics & Child Health & SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.
Ana C ZenclussenHelmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
Yining ZhangDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Lea ZillichDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0001-7457-374X
Rosalind WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jari Lahti *University of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland.ORCID 0000-0002-4310-5297
Kelly J Brunst *University of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA. Kelly.Brunst@uc.edu.
Heidelberg University · DEErasmus MC · NLMax Planck Institute of Psychiatry · DEUniversity of Helsinki · FIHelmholtz Centre for Environmental Research · DENorwegian Institute of Public Health · NOSouth African Medical Research Council · ZAEmory University · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · USUniversity of Bristol · GBUniversity of Exeter · GBUniversity of Michigan · USUniversity of California, Davis · USUniversity of Cape Town · ZAUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · US
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MREPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4MGene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0MPilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6MThe Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3MUC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5MMolecular Epidemiology in Children's Environmental Health Training Program (MECEH)T32ES010957 · NIEHS · UNIVERSITY OF CINCINNATI · PI Kelly J Brunst · 2001 to 2026
$11.1MBuilding Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6MAutism Risk, Prenatal Environmental Exposures, and Pathophysiologic MarkersR01ES020392 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, OZONOFF, SALLY · 2011 to 2015
$9.0MGenetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8MEnvironmental Influence on Infant Microbiome Development and ASD SymptomsR01ES028089 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA, MILLS, DAVID ANDREW · 2016 to 2020
$3.6MPrenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2MIntramural NIH HHS Z01 ES049019Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MR/S009310/1Medical Research Council MR/S036520/1NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL095606NHLBI NIH HHS R01 HL114396NICHD NIH HHS K12 HD051958NICHD NIH HHS R01 HD068437NICHD NIH HHS R21 HD085849NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES024116NIEHS NIH HHS R01 ES020392NIEHS NIH HHS R01 ES025531NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R01 ES028089NIEHS NIH HHS R24 ES028533NIEHS NIH HHS T32 ES010957NINDS NIH HHS U01 NS047537
Abstract
Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N = 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3. Stressor-specific domains of conflict with family/friends, abuse (physical, sexual, and emotional), and death of a close friend/relative were also associated with differential methylation of CpGs in APTX, MyD88, and both UHRF1 and SDCCAG8, respectively; these genes are implicated in neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. Thus, differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring.
Indexed as
DNA MethylationEpigenesis, GeneticEpigenomePrenatal Exposure Delayed EffectsStress, PsychologicalAdultFemaleFetal BloodHumansInfant, NewbornLongitudinal StudiesMothersPregnancy
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