ArticleInternational journal of obesity (2005)2023
Association of metabolically healthy obesity in young adulthood with myocardial structure and function.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Ventricular Remodeling and Subclinical Dysfunction in Pediatric Obesity: Echocardiographic Links to Weight and Abdominal Fat.Pediatric cardiology · 2026Article
- Metabolic health phenotypes and cardiovascular disease among U.S. adults with central obesity: Evidence from NHANES 2011- March 2020.Obesity pillars · 2026Article
- Beyond the BMI Paradox: Unraveling the Cellular and Molecular Determinants of Metabolic Health in Obesity.Biomolecules · 2025Review
- Network study of the nutritional patterns, the metabolic and the psychological status among overweight-obese young adults.Frontiers in nutrition · 2025Article
- Beyond Cardiometabolic: Health Disorders Risk in Metabolically Healthy Obese Children - A Systematic Review and Meta-Analysis of 19,119 Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Association of Anthropometric Indices With Midlife Cardiovascular Risk in Young Individuals Without Obesity and Traditional Risk Factors.Journal of the American Heart Association · 2024Article
- Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity.Cell metabolism · 2024Article
- Metabolic health's central role in chronic kidney disease progression: a 20-year study of obesity-metabolic phenotype transitions.Scientific reports · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function.
methodsA total of 3066 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included, who completed echocardiography in young adulthood and middle age. The participants were grouped by obesity status (body mass index ≥30 kg/m
resultsAt baseline, mean age was 25 years, 56.4% were women, and 44.7% were black. After a follow-up 25 years, MUN in young adulthood was associated with worse LV diastolic function (E/é ratio, β [95% CI], 0.73 [0.18, 1.28]), worse systolic function (global longitudinal strain [GLS], 0.60 [0.08, 1.12]) in comparison with MHN. MHO and MUO were associated with LV hypertrophy (LV mass index, 7.49 g/m
conclusionsIn this community-based cohort using data from the CARDIA study, obesity in young adulthood was significantly associated with LV hypertrophy, worse systolic and diastolic function regardless of metabolic status. Relationship of Baseline Metabolic Phenotypes with Young Adulthood and Midlife Cardiac Structure and Function. Adjusted for year 0 covariates: age, sex, race, educational level, smoking status, drinking status, and physical activity; metabolically healthy non-obesity was used as a reference category for comparison.
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