Evidence map›Paper›PMID 36899020›Full record

ArticleNature communications2023

Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation.

Nannan Guo, Na Li, Li Jia, Qinyue Jiang, Mette Schreurs, Vincent van Unen, Susana M Chuva de Sousa Lopes, Alexandra A Vloemans, Jeroen Eggermont, Boudewijn Lelieveldt and 4 more

Open access · goldFull text read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Immune development in early life.Nature immunology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 3 countries.

Nannan GuoDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-2661-8824
Na LiDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Li JiaDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Qinyue JiangDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Mette SchreursDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-2097-1600
Vincent van UnenDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-9339-8430
Susana M Chuva de Sousa LopesDepartment of Anatomy, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-3866-2803
Alexandra A VloemansDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Jeroen EggermontDepartment of Radiology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-0361-9469
Boudewijn LelieveldtDepartment of Radiology, Leiden University Medical Center, Leiden, Netherlands.
Frank J T StaalDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-1588-8519
Noel F C C de MirandaDepartment of Pathology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-6122-1024
M Fernanda Pascutti *Department of Immunology, Leiden University Medical Center, Leiden, Netherlands. M.F.Pascutti@lumc.nl.
Frits Koning *Department of Immunology, Leiden University Medical Center, Leiden, Netherlands. F.Koning@lumc.nl.ORCID 0000-0002-4007-5715
Leiden University Medical Center · NLJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestine represents the largest immune compartment in the human body, yet its development and organisation during human foetal development is largely unknown. Here we show the immune subset composition of this organ during development, by longitudinal spectral flow cytometry analysis of human foetal intestinal samples between 14 and 22 weeks of gestation. At 14 weeks, the foetal intestine is mainly populated by myeloid cells and three distinct CD3

Indexed as

Interleukin-7IntestinesFemaleFetusHumansIntestinal MucosaLymphocytesPregnancyPregnancy Trimester, SecondT-Lymphocyte SubsetsInterleukin-7

Identifiers

PMID36899020
PMCPMC10006174
OpenAlexW4323864137

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read64
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.