Evidence map›Paper›PMID 36898851›Full record

ArticleCancer science2023

EBV-positive pyothorax-associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3.

Tomonori Higuchi, Yumiko Hashida, Kazuhiko Matsuo, Kosuke Kitahata, Takako Ujihara, Ichiro Murakami, Takashi Nakayama, Masanori Daibata

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tomonori HiguchiDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Japan.ORCID https://orcid.org/0000-0003-1428-3040
Yumiko HashidaDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Japan.
Kazuhiko MatsuoDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-Osaka, Japan.
Kosuke KitahataDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-Osaka, Japan.
Takako UjiharaDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Japan.
Ichiro MurakamiDepartment of Pathology, Kochi Medical School, Kochi University, Nankoku, Japan.
Takashi NakayamaDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-Osaka, Japan.
Masanori DaibataDepartment of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Japan.ORCID https://orcid.org/0000-0001-8714-2068
Kochi Medical School Hospital · JPKindai University · JP

Funding

Japan Society for the Promotion of Science 20K08714
6 · The paper itself

Abstract

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) develops in the setting of long-standing inflammation. This type of lymphoma may have specific expression profiles of chemokines involved in the pathogenesis of DLBCL-CI. EBV-positive pyothorax-associated lymphoma (PAL) is a prototype of DLBCL-CI and represents a valuable model for the study of this disease category. Using a panel of PAL cell lines, we found that PAL cells expressed and secreted C-X-C motif chemokine ligands 9 and 10 (CXCL9 and CXCL10), the ligands of CXCR3, in contrast to EBV-negative DLBCL cell lines, which did not. Culture supernatants from PAL cell lines attracted CXCR3-expressing CD4

Indexed as

Empyema, PleuralEpstein-Barr Virus InfectionsLymphoma, Large B-Cell, DiffuseAnimalsCD8-Positive T-LymphocytesChemokine CXCL10Chemokine CXCL9Herpesvirus 4, HumanHumansInflammationKiller Cells, NaturalLeukocytes, MononuclearLigandsMiceReceptors, CXCR3Chemokine CXCL10Chemokine CXCL9CXCL10 protein, humanCXCL9 protein, humanCXCR3 protein, humanLigandsReceptors, CXCR3chemokinecytotoxic lymphocyteEpstein-Barr virusinflammationlymphoma

Identifiers

PMID36898851
PMCPMC10236606
OpenAlexW4323817139

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.