Evidence map›Paper›PMID 36898758›Full record

ArticleBMJ open2023

Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics (STARSHIP): protocol to study cerebral autoregulation in a prospective multicentre observational research database study.

Shruti Agrawal, Michal M Placek, Deborah White, Esther Daubney, Manuel Cabeleira, Peter Smielewski, Marek Czosnyka, Adam Young, Suzanna Watson, Anna Maw and 1 more

Registry-linked trialOpen access · goldFull text readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05688462 (Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05688462 completednot on this map

Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics

Typeobservational_patient_registrySponsorShruti AgrawalRan2018 to 2025Enrolled135ConditionsTBI (Traumatic Brain Injury)ArmsData Collection
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shruti AgrawalDepartment of Paediatrics, Cambridge University, Cambridge, UK shruti.agrawal1@nhs.net.ORCID 0000-0001-8695-1314
Michal M PlacekDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Deborah WhitePaediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Esther DaubneyPaediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Manuel CabeleiraDepartment of Mechanical Engineering, University College London, London, UK.
Peter SmielewskiDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Marek CzosnykaDepartment of Paediatrics, Cambridge University, Cambridge, UK.
Adam YoungDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Suzanna WatsonPaediatric Neuropsychology, Cambridge Centre for Paediatric Neuropsychological Rehabilitation, Cambridge, UK.
Anna MawPaediatric Neurologi, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Peter John HutchinsonAcademic Neurosurgery, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2796-1835
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStudying cerebral autoregulation, particularly PRx (Pressure Reactivity Index), is commonly employed in adult traumatic brain injury (TBI) and gives real-time information about intracranial pathophysiology, which can help in patient management. Experience in paediatric TBI (PTBI) is limited to single-centre studies despite disproportionately higher incidence of morbidity and mortality in PTBI than in adult TBI. PROJECT: We describe the protocol to study cerebral autoregulation using PRx in PTBI. The project called Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics is a multicentre prospective ethics approved research database study from 10 centres across the UK. Recruitment started in July 2018 with financial support from local/national charities (Action Medical Research for Children, UK). METHODS AND ANALYSIS: The first phase of the project is powered to detect optimal thresholds of PRx associated with favourable outcome in PTBI by recruiting 135 patients (initial target of 3 years which has changed to 5 years due to delays related to COVID-19 pandemic) from 10 centres in the UK with outcome follow-up to 1-year postictus. The secondary objectives are to characterise patterns of optimal cerebral perfusion pressure in PTBI and compare the fluctuations in these measured parameters with outcome. The goal is to create a comprehensive research database of a basic set of high-resolution (full waveforms resolution) neuromonitoring data in PTBI for scientific use. ETHICS AND DISSEMINATION: Favourable ethical approval has been provided by Health Research Authority, Southwest-Central Bristol Research Ethics Committee (Ref: 18/SW/0053). Results will be disseminated via publications in peer-reviewed medical journals and presentations at national and international conferences. TRIAL REGISTRATION NUMBER: NCT05688462.

Indexed as

Brain Injuries, TraumaticCOVID-19AdultCerebrovascular CirculationChildHomeostasisHumansIntracranial PressureMulticenter Studies as TopicObservational Studies as TopicPandemicsProspective Studiesneurological injurypaediatric intensive & critical carephysiologytrauma management

Identifiers

PMID36898758
PMCPMC10008199
OpenAlexW4323864316

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read2
identifiers read1
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.