Evidence map›Paper›PMID 36898755›Full record

ArticleBMJ open2023

Harnessing neuroplasticity to improve motor performance in infants with cerebral palsy: a study protocol for the GAME randomised controlled trial.

Catherine Morgan, Nadia Badawi, Roslyn N Boyd, Alicia J Spittle, Russell C Dale, Adrienne Kirby, Rod W Hunt, Koa Whittingham, Kerstin Pannek, Rachael L Morton and 10 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. HEPChildren (Basel, Switzerland) · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Catherine MorganCerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia cmorgan@cerebralpalsy.org.au.ORCID 0000-0003-3670-0845
Nadia BadawiCerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health, The University of Sydney, Sydney, New South Wales, Australia.
Roslyn N BoydThe Faculty of Medicine, Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Alicia J SpittleFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-6535-661X
Russell C DaleChildren's Hospital at Westmead Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
Adrienne KirbyFaculty of Medicine and Health, NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
Rod W HuntDepartment of Paediatrics, Monash University, Clayton, Victoria, Australia.
Koa WhittinghamQueensland Cerebral Palsy Research Centre, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-5344-9907
Kerstin PannekHealth and Biosecurity, The Australian E-Health Research Centre, CSIRO, Brisbane, Queensland, Australia.
Rachael L MortonFaculty of Medicine and Health, NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
William Tarnow-MordiNHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.
Michael C FaheyDepartment of Paediatrics, Monash University, Clayton, Victoria, Australia.
Karen WalkerFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Kristina PrelogMedical Imaging Department, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Catherine ElliottSchool of Allied Health, Curtin University, Perth, Western Australia, Australia.
Jane ValentinePaediatric Rehabilitation, Princess Margaret Hospital for Children, Perth, Western Australia, Australia.
Andrea GuzzettaDepartment of Developmental Neuroscience, IRCCS Stella Maris, University of Pisa, Pisa, Toscana, Italy.
Shannon OliveyCerebral Palsy Alliance, Forestville, New South Wales, Australia.
GAME study team
Iona NovakFaculty of Medicine & Health, The University of Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCerebral palsy (CP) is the most common physical disability of childhood worldwide. Historically the diagnosis was made between 12 and 24 months, meaning data about effective early interventions to improve motor outcomes are scant. In high-income countries, two in three children will walk. This evaluator-blinded randomised controlled trial will investigate the efficacy of an early and sustained Goals-Activity-Motor Enrichment approach to improve motor and cognitive skills in infants with suspected or confirmed CP. METHODS AND ANALYSIS: Participants will be recruited from neonatal intensive care units and the community in Australia across four states. To be eligible for inclusion infants will be aged 3-6.5 months corrected for prematurity and have a diagnosis of CP or 'high risk of CP' according to the International Clinical Practice Guideline criteria. Eligible participants whose caregivers consent will be randomly allocated to receive usual care or weekly sessions at home from a GAME-trained study physiotherapist or occupational therapist, paired with a daily home programme, until age 2. The study requires 150 participants per group to detect a 0.5 SD difference in motor skills at 2 years of age, measured by the Peabody Developmental Motor Scales-2. Secondary outcomes include gross motor function, cognition, functional independence, social-emotional development and quality of life. A within-trial economic evaluation is also planned. ETHICS AND DISSEMINATION: Ethical approval was obtained from the Sydney Children's Hospital Network Human Ethics Committee in April 2017 (ref number HREC/17/SCHN/37). Outcomes will be disseminated through peer-reviewed journal publications, presentations at international conferences and consumer websites. TRIAL REGISTRATION NUMBER: ACTRN12617000006347.

Indexed as

Cerebral PalsyAustraliaChildCognitionHumansInfantInfant, NewbornNeuronal PlasticityQuality of LifeRandomized Controlled Trials as Topiccommunity child healthpaediatric neurologyrehabilitation medicine

Identifiers

PMID36898755
PMCPMC10008404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.