Evidence map›Paper›PMID 36897981›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Using conditional independence tests to elucidate causal links in cell cycle regulation in

Prathitha Kar, Sriram Tiruvadi-Krishnan, Jaana Männik, Jaan Männik, Ariel Amir

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Clocks and Dominoes: Timing Mechanisms of Embryogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. Regulatory elements coordinating initiation of chromosome replication to theProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Recollections of a Helmstetter Disciple.Life (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Prathitha KarJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134.ORCID 0000-0002-4091-6860
Sriram Tiruvadi-KrishnanDepartment of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996.ORCID 0000-0002-0423-909X
Jaana MännikDepartment of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996.ORCID 0000-0002-0777-7846
Jaan MännikDepartment of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996.ORCID 0000-0002-6759-3053
Ariel AmirJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02134.
University of Tennessee at Knoxville · USHarvard University · US

Funding

Coordination mechanisms between cell division and chromosome segregation in E. coliR01GM127413 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jaan Mannik · 2018 to 2026
$2.5M
NIGMS NIH HHS R01 GM127413NIH HHS 103346
6 · The paper itself

Abstract

How cells regulate their cell cycles is a central question for cell biology. Models of cell size homeostasis have been proposed for bacteria, archaea, yeast, plant, and mammalian cells. New experiments bring forth high volumes of data suitable for testing existing models of cell size regulation and proposing new mechanisms. In this paper, we use conditional independence tests in conjunction with data of cell size at key cell cycle events (birth, initiation of DNA replication, and constriction) in the model bacterium

Indexed as

Escherichia coliEscherichia coli ProteinsCell CycleCell DivisionDNA ReplicationEscherichia coli Proteinscell cycleconditional independenceEscherichia coli

Identifiers

PMID36897981
PMCPMC10089181
OpenAlexW4323825232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.