Evidence map›Paper›PMID 36897951›Full record

ArticleScience advances2023

Spectral imaging enables contrast agent-free real-time ischemia monitoring in laparoscopic surgery.

Leonardo Ayala, Tim J Adler, Silvia Seidlitz, Sebastian Wirkert, Christina Engels, Alexander Seitel, Jan Sellner, Alexey Aksenov, Matthias Bodenbach, Pia Bader and 11 more

Full text read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Artificial intelligence in urology training Enhancing annotation, feedback, and evaluation in robotic, laparoscopic, and endoscopic surgery.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
    Review
  4. Neural illumination calibration for surgical workflow-optimized spectral imaging.International journal of computer assisted radiology and surgery · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Semantic hyperspectral image synthesis for cross-modality knowledge transfer in surgical data science.International journal of computer assisted radiology and surgery · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. A dual-camera hyperspectral laparoscopic imaging system.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Leonardo AyalaDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-3574-2085
Tim J AdlerDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-3424-6629
Silvia SeidlitzDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1122-4793
Sebastian WirkertDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christina EngelsStädtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Alexander SeitelDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-5919-9646
Jan SellnerDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-4469-8343
Alexey AksenovStädtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Matthias BodenbachStädtisches Klinikum Karlsruhe, Karlsruhe, Germany.ORCID 0000-0003-1471-0444
Pia BaderStädtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Sebastian BaronStädtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Anant VemuriDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-3663-7962
Manuel WiesenfarthDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nicholas SchreckDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9277-4297
Diana MindrocDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-3104-2129
Minu TizabiDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sebastian PirmannDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brittaney EverittDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7804-6568
Annette Kopp-SchneiderDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1810-0267
Dogu TeberStädtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Lena Maier-HeinDivision of Intelligent Medical Systems, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-4910-9368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laparoscopic surgery has evolved as a key technique for cancer diagnosis and therapy. While characterization of the tissue perfusion is crucial in various procedures, such as partial nephrectomy, doing so by means of visual inspection remains highly challenging. We developed a laparoscopic real-time multispectral imaging system featuring a compact and lightweight multispectral camera and the possibility to complement the conventional surgical view of the patient with functional information at a video rate of 25 Hz. To enable contrast agent-free ischemia monitoring during laparoscopic partial nephrectomy, we phrase the problem of ischemia detection as an out-of-distribution detection problem that does not rely on data from any other patient and uses an ensemble of invertible neural networks at its core. An in-human trial demonstrates the feasibility of our approach and highlights the potential of spectral imaging combined with advanced deep learning-based analysis tools for fast, efficient, reliable, and safe functional laparoscopic imaging.

Indexed as

Contrast MediaLaparoscopyHumansIschemiaNephrectomyNeural Networks, ComputerContrast Media

Identifiers

PMID36897951
PMCPMC10005169

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Textfull text, public
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.