Evidence map›Paper›PMID 36897942›Full record

ArticleScience advances2023

Structure-guided engineering of a receptor-agonist pair for inducible activation of the ABA adaptive response to drought.

Jorge Lozano-Juste, Lourdes Infantes, Irene Garcia-Maquilon, Rafael Ruiz-Partida, Ebe Merilo, Juan Luis Benavente, Adrian Velazquez-Campoy, Alberto Coego, Mar Bono, Javier Forment and 7 more

Open access · goldFull text read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Evolutionary-based remodeling of ABA receptors reveals the structural basis of hormone perception and regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. A Potential ABA Analog to Increase Drought Tolerance inInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Jorge Lozano-JusteInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.ORCID 0000-0001-7034-566X
Lourdes InfantesInstituto de Química Física Rocasolano, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.ORCID 0000-0001-6932-4212
Irene Garcia-MaquilonInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.
Rafael Ruiz-PartidaInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.
Ebe MeriloInstitute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.ORCID 0000-0003-1767-6413
Juan Luis BenaventeInstituto de Química Física Rocasolano, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.
Adrian Velazquez-CampoyInstitute of Biocomputation and Physics of Complex Systems (BIFI), Joint Units GBsC-CSIC-BIFI and ICVV-CSIC-BIFI, Universidad de Zaragoza, Mariano Esquillor s/n, 50018 Zaragoza, Spain.ORCID 0000-0001-5702-4538
Alberto CoegoInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.ORCID 0000-0002-2459-4291
Mar BonoInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.ORCID 0000-0002-6495-7069
Javier FormentInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.ORCID 0000-0002-1872-4061
Begoña PampínGalChimia S.A., Parque Empresarial de Touro, Parcelas 26-27, Fonte Díaz, 15822 Touro, A Coruña, Spain.
Paolo DestitoGalChimia S.A., Parque Empresarial de Touro, Parcelas 26-27, Fonte Díaz, 15822 Touro, A Coruña, Spain.
Adrián MonteiroGalChimia S.A., Parque Empresarial de Touro, Parcelas 26-27, Fonte Díaz, 15822 Touro, A Coruña, Spain.ORCID 0000-0002-9786-3640
Ramón RodríguezGalChimia S.A., Parque Empresarial de Touro, Parcelas 26-27, Fonte Díaz, 15822 Touro, A Coruña, Spain.ORCID 0000-0002-6624-541X
Jacobo CrucesGalChimia S.A., Parque Empresarial de Touro, Parcelas 26-27, Fonte Díaz, 15822 Touro, A Coruña, Spain.
Pedro L RodriguezInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, 46022 Valencia, Spain.ORCID 0000-0002-5886-9425
Armando AlbertInstituto de Química Física Rocasolano, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.ORCID 0000-0002-0026-6816
Consejo Superior de Investigaciones Científicas · ESUnited Parcel Service (United States) · USUniversidad de Zaragoza · ESUniversity of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies to activate abscisic acid (ABA) receptors and boost ABA signaling by small molecules that act as ABA receptor agonists are promising biotechnological tools to enhance plant drought tolerance. Protein structures of crop ABA receptors might require modifications to improve recognition of chemical ligands, which in turn can be optimized by structural information. Through structure-based targeted design, we have combined chemical and genetic approaches to generate an ABA receptor agonist molecule (iSB09) and engineer a CsPYL1 ABA receptor, named CsPYL1

Indexed as

ArabidopsisArabidopsis ProteinsAbscisic AcidCarrier ProteinsDroughtsGene Expression Regulation, PlantLigandsAbscisic AcidArabidopsis ProteinsCarrier ProteinsLigands

Identifiers

PMID36897942
PMCPMC10005185
OpenAlexW4323920751

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read93
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.