ArticleDrug delivery and translational research2023
An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management.
Article in Drug delivery and translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A Review of Virtual Twins in Physiologically-Based Pharmacokinetic Modeling and Simulation.Clinical pharmacology and therapeutics · 2026Review
- NIPTE 2030: The Nation's Digital Trust Anchor for Pharma 5.0.Pharmaceutical research · 2026Article
- Human digital twins in women's health nursing.Women's health nursing (Seoul, Korea) · 2026Article
- Research on Prediction of Preterm Birth Risk Based on Digital Twin Technology.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Digital therapeutics into geriatric cardiovascular emergency care.Frontiers in digital health · 2026Review
- Analgesic efficacy in women and men with cancer pain, treated with strong opioids: are there differences?BMJ oncology · 2026Article
- Application of Digital Twin Technology to Enhance Chronic Diseases Management: A Systematic Review.International journal of telemedicine and applications · 2026Review
- Ethical and Quality of Care-Related Challenges of Digital Health Twins in Care Settings for Older Adults: Scoping Review.JMIR aging · 2025Article
- A scoping review of human digital twins in healthcare applications and usage patterns.NPJ digital medicine · 2025Article
- From virtual to reality: innovative practices of digital twins in tumor therapy.Journal of translational medicine · 2025Review
- Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members' vision - part 2.The journal of headache and pain · 2025Review
- Beyond the gender data gap: co-creating equitable digital patient twins.Frontiers in digital health · 2025Review
- Digital twins in healthcare: a comprehensive review and future directions.Frontiers in digital health · 2025Review
- Personalised Transdermal Therapy for Chronic Pain with Digital Twin Technology.Current drug targets · 2025Review
- Article
- Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review.Journal of medical Internet research · 2024Article
- Article
- Evolution of digital twins in precision health applications: a scoping review study.Research square · 2024Article
- The effectiveness of digital twins in promoting precision health across the entire population: a systematic review.NPJ digital medicine · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fentanyl transdermal therapy is a suitable treatment for moderate-to-severe cancer-related pain. The inter-individual variability of the patients leads to different therapy responses. This study aims to determine the effect of physiological features on the achieved pain relief. Therefore, a set of virtual patients was developed by using Markov chain Monte Carlo (MCMC) based on actual patient data. The members of this virtual population differ by age, weight, gender, and height. Tailored digital twins were developed using these correlated, individualized parameters to propose a personalized therapy for each patient. It was shown that patients of different ages, weights, and gender have significantly different fentanyl blood uptake, plasma fentanyl concentration, pain relief, and ventilation rate. In the digital twins, we included the virtual patients' response to the treatment, namely, pain relief. Therefore, the digital twin was able to adjust the therapy in silico to have more efficient pain relief. By implementing digital-twin-assisted therapy, the average pain intensity decreased by 16% compared to conventional therapy. The median time without pain increased by 23 h over 72 h. Therefore, the digital twin can be successfully used in individual control of transdermal therapy to reach higher pain relief and maintain steady pain relief. (Created with BioRender.com).
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