Evidence map›Paper›PMID 36897330›Full record

ArticleThe Journal of experimental medicine2023

License to kill: Retinoic acid programs T cells for tissue residency.

Maximilian Heeg, Ananda W Goldrath

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Insights into phenotypic and functional CD8Immunological reviews · 2023
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maximilian HeegDepartment of Molecular Biology, University of California, San Diego , La Jolla, CA, USA.ORCID 0000-0002-9594-1377
Ananda W GoldrathDepartment of Molecular Biology, University of California, San Diego , La Jolla, CA, USA.ORCID 0000-0002-5900-508X
University of California San Diego · US

Funding

Transcription factor regulation of CD4 and CD8 T cell effector and memory differentiation and functionP01AI145815 · NIAID · UNIVERSITY OF FLORIDA · PI PIPKIN, MATTHEW EUGENE · 2020 to 2024
$11.0M
Single-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8M
NIAID NIH HHS P01 AI132122NIAID NIH HHS P01 AI145815
6 · The paper itself

Abstract

In this issue of JEM, Qiu et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20210923) show that retinoic acid signaling during priming in the mesenteric lymph node licenses CD8+ T cells to develop into small intestinal tissue-resident memory cells, a finding that provides key insights into tissue-specific vaccination strategies.

Indexed as

CD8-Positive T-LymphocytesTretinoinCell DifferentiationLymph NodesTretinoin

Identifiers

PMID36897330
PMCPMC10035436
OpenAlexW4323812022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.