Evidence map›Paper›PMID 36897303›Full record

ArticleSchizophrenia bulletin2023

Differential Trajectories of Delusional Content and Severity Over 2 Years of Early Intervention for Psychosis: Comparison Between Chennai, India, and Montréal, Canada.

Ann-Catherine Lemonde, Srividya N Iyer, Ashok Malla, Thara Rangaswamy, Ramachandran Padmavati, Greeshma Mohan, Aarati Taksal, Genevieve Gariepy, Ridha Joober, Patricia Boksa and 1 more

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ann-Catherine LemondeDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, Canada.ORCID 0000-0003-1344-9416
Srividya N IyerDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, Canada.ORCID 0000-0001-5367-9086
Ashok MallaDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, Canada.ORCID 0000-0002-5863-4191
Thara RangaswamySchizophrenia Research Foundation (SCARF), Chennai, India.ORCID 0000-0001-6813-066X
Ramachandran PadmavatiSchizophrenia Research Foundation (SCARF), Chennai, India.ORCID 0000-0002-0380-8617
Greeshma MohanSchizophrenia Research Foundation (SCARF), Chennai, India.ORCID 0000-0002-6322-5413
Aarati TaksalPrevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montréal, Canada.ORCID 0000-0003-4125-7585
Genevieve GariepyPublic Health Agency of Canada, Ottawa, Canada.
Ridha JooberDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, Canada.ORCID 0000-0003-3492-807X
Patricia BoksaDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, Canada.
Jai L ShahDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, Canada.ORCID 0000-0002-7549-6990
Douglas Mental Health University Institute · CASchizophrenia Research Foundation · INMcGill University · CAPublic Health Agency of Canada · CA

Funding

Early Psychosis in India and Canada: Investigating outcomes and family factorsR01MH093303 · NIMH · MCGILL UNIVERSITY · PI MALLA, ASHOK · 2012 to 2016
$2.3M
NIH HHS NIH5R01MH093303-05NIMH NIH HHS R01 MH093303
6 · The paper itself

Abstract

backgroundThere exist few direct studies of delusional content in psychosis across geo-cultural contexts, especially those in which treatment protocols and measures are comparable. To directly examine an illness outcome that is potentially culturally mediated, this study investigated the baseline presentation and longitudinal trajectory of delusions in first-episode psychosis (FEP) across 2 similar treatment settings in Montréal (Canada) and Chennai (India). STUDY

designPatients entering an early intervention program for FEP in Chennai (N = 168) and Montréal (N = 165) were compared on site-level differences in the presentation of delusions across specific time points over 2 years of treatment. Delusions were measured using the Scale for Assessment of Positive Symptoms. Chi-square and regression analyses were conducted. STUDY

resultsAt baseline, delusions were more frequent in Montréal than in Chennai (93% vs 80%, respectively; X2(1) = 12.36, P < .001). Thematically, delusions of grandiosity, religiosity, and mind reading were more common in Montréal than in Chennai (all P < .001); however, these baseline differences did not persist over time. Regression revealed a significant time-by-site interaction in the longitudinal course of delusions, which differs from the trajectory of other FEP-positive symptom domains.

conclusionsTo the best of our knowledge, this is the first direct comparison of delusions in similar programs for FEP across 2 different geo-cultural contexts. Our findings support the notion that delusion themes follow consistent ordinal patterns across continents. Future work is needed to unpack the differences in severity that present at baseline and minor differences in content.

Indexed as

Psychotic DisordersCanadaDelusionsHumansIndiaMood Disordersdelusionsfirst episode psychosisgeo-cultural contextsymptomatology

Identifiers

PMID36897303
PMCPMC10318872
OpenAlexW4323807816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.