Evidence map›Paper›PMID 36897228›Full record

ReviewEpilepsia2023

Passive and active markers of cortical excitability in epilepsy.

Georgia Ramantani, M Brandon Westover, Stephen Gliske, Johannes Sarnthein, Sridevi Sarma, Yujiang Wang, Maxime O Baud, William C Stacey, Erin C Conrad

Abstract readReview
In one paragraph

Review in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  9. Article
  10. Review
  11. On brain stimulation in epilepsy.Brain : a journal of neurology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Georgia RamantaniDepartment of Neuropediatrics and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-7931-2327
M Brandon WestoverDepartment of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0003-4803-312X
Stephen GliskeDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-2259-2612
Johannes SarntheinDepartment of Neurosurgery, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9141-381X
Sridevi SarmaDepartment of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-4817-6625
Yujiang WangInterdisciplinary Computing and Complex BioSystems, School of Computing Science, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0002-4847-6273
Maxime O BaudSleep-Wake-Epilepsy Center, NeuroTec, Center for Experimental Neurology, Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-8297-7696
William C StaceyDepartment of Neurology, BioInterfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8359-8057
Erin C ConradCenter for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8910-1817

Funding

Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3M
Characterizing High Frequency Oscillations as an epilepsy biomarker with Big Data toolsR01NS094399 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STACEY, WILLIAM CHARLES · 2015 to 2025
$4.1M
Comparative Safety of Seizure Prophylaxis within the Medicare ProgramR01AG073410 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lidia Maria Veras Rocha de Moura · 2021 to 2026
$4.1M
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionR01AG073598 · NIA · STANFORD UNIVERSITY · PI Miles Berger · 2022 to 2026
$3.8M
Integrative Motor Activity Biomarker for the Risk of Alzheimer's RiskRF1AG064312 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2019 to 2019
$3.6M
Multimodal Network Connectivity Architecture (MOCA) of the Brain and its Role in the Recovery of Consciousness in Comatose Cardiac Arrest PatientsR01NS102574 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GREER, DAVID MATTHEW, WU, ONA · 2018 to 2022
$3.4M
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)R01NS102190 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$3.2M
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
CRCNS: Following the BOLD lightening at rest strikes the seizure onset zone!R01NS125897 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOERWINKLE, VARINA · 2021 to 2025
$1.7M
Quantitative interictal networks to localize seizure generatorsK23NS121401 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Erin Conrad · 2022 to 2026
$1.2M
NHLBI NIH HHS R01 HL161253NHLBI NIH HHS R01HL161253NIA NIH HHS R01 AG073410NIA NIH HHS R01AG073410NIA NIH HHS R01 AG073598NIA NIH HHS R01AG073598NIA NIH HHS RF1 AG064312NIA NIH HHS RF1AG064312NIEHS NIH HHS K01 ES026839NIEHS NIH HHS K01ES026839NINDS NIH HHS K23 NS121401NINDS NIH HHS K23NS121401NINDS NIH HHS R01 NS094399NINDS NIH HHS R01NS094399NINDS NIH HHS R01 NS102190NINDS NIH HHS R01NS102190NINDS NIH HHS R01 NS102574NINDS NIH HHS R01NS102574NINDS NIH HHS R01 NS107291NINDS NIH HHS R01NS107291NINDS NIH HHS R01 NS125897NINDS NIH HHS R01NS125897NINDS NIH HHS R01 NS126282NINDS NIH HHS R01NS126282NINDS NIH HHS RF1 NS120947NINDS NIH HHS RF1NS120947Wellcome Trust 204651
6 · The paper itself

Abstract

Electroencephalography (EEG) has been the primary diagnostic tool in clinical epilepsy for nearly a century. Its review is performed using qualitative clinical methods that have changed little over time. However, the intersection of higher resolution digital EEG and analytical tools developed in the past decade invites a re-exploration of relevant methodology. In addition to the established spatial and temporal markers of spikes and high-frequency oscillations, novel markers involving advanced postprocessing and active probing of the interictal EEG are gaining ground. This review provides an overview of the EEG-based passive and active markers of cortical excitability in epilepsy and of the techniques developed to facilitate their identification. Several different emerging tools are discussed in the context of specific EEG applications and the barriers we must overcome to translate these tools into clinical practice.

Indexed as

Cortical ExcitabilityEpilepsyElectroencephalographyHumanscortical excitabilityEEG biomarkersepilepsyhigh-frequency oscillationsinterictal spikes

Identifiers

PMID36897228
PMCPMC10512778

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.