Evidence map›Paper›PMID 36897177›Full record

ArticleObstetrics and gynecology2023

Postpartum Opioid-Related Mortality in Patients With Public Insurance.

Elizabeth A Suarez, Krista F Huybrechts, Loreen Straub, Sonia Hernández-Díaz, Andreea A Creanga, Hilary S Connery, Kathryn J Gray, Seanna M Vine, Hendrée E Jones, Brian T Bateman

Open access · greenAbstract read
In one paragraph

Article in Obstetrics and gynecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Trends in Prenatal Opioid Use Disorder in California, 2010-2022.American journal of preventive medicine · 2025
    Article
  5. Hospital Care for Pregnant Persons With OUD Review.American journal of medicine open · 2025
    Review
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  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Elizabeth A SuarezDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, the Department of Epidemiology, Harvard T.H. Chan School of Public Health, and the Department of Psychiatry, Harvard Medical School, Boston, and the Division of Alcohol, Drugs, and Addiction, McLean Hospital, Belmont, Massachusetts; the Departments of International Health and Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland; UNC Horizons and the Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.
Krista F Huybrechts
Loreen Straub
Sonia Hernández-Díaz
Andreea A Creanga
Hilary S Connery
Kathryn J Gray
Seanna M Vine
Hendrée E Jones
Brian T Bateman
Johns Hopkins University · USUniversity of North Carolina at Chapel Hill · USHarvard University · USBrigham and Women's Hospital · USMcLean Hospital · US

Funding

The Comparative Effectiveness and Safety of Pharmacotherapies for the Treatment of Opioid Use Disorder in PregnancyR01DA049822 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI Brian Thomas Bateman, Krista F Huybrechts · 2020 to 2026
$5.4M
NIDA NIH HHS R01 DA049822
6 · The paper itself

Abstract

objectiveTo assess the incidence and risk factors for postpartum opioid overdose death and describe other causes of postpartum death in individuals with opioid use disorder (OUD).

methodsWe conducted a cohort study that used health care utilization data from the Medicaid Analytic eXtract linked to the National Death Index in the United States from 2006 to 2013. All pregnant individuals with live births or stillbirths and continuous enrollment for 3 months before delivery were eligible, including 4,972,061 deliveries. A subcohort of individuals with a documented history of OUD in the 3 months before delivery was identified. We estimated the cumulative incidence of death as occurring between delivery and 1 year postpartum among all individuals and individuals with OUD. Risk factors for opioid overdose death were assessed using odds ratios (ORs) and descriptive statistics, including demographics, health care utilization, obstetric conditions, comorbidities, and medications.

resultsThe incidence of postpartum opioid overdose death per 100,000 deliveries was 5.4 (95% CI 4.5-6.4) among all individuals and 118 (95% CI 84-163) among individuals with OUD. Individuals with OUD had a sixfold higher incidence of all-cause postpartum death than all individuals. Common causes of death in individuals with OUD were other drug- and alcohol-related deaths (47/100,000), suicide (26/100,000), and other injuries, including accidents and falls (33/100,000). Risk factors strongly associated with postpartum opioid overdose death included mental health and other substance use disorders. Among patients with OUD, postpartum use of medication to treat OUD was associated with 60% lower odds of opioid overdose death (OR 0.4, 95% CI 0.1-0.9).

conclusionPostpartum individuals with OUD have a high incidence of postpartum opioid overdose death and other preventable deaths, including nonopioid substance-related injuries, accidents, and suicide. Use of medications for OUD is strongly associated with lower opioid-related mortality.

Indexed as

Drug OverdoseInsuranceOpiate OverdoseOpioid-Related DisordersAnalgesics, OpioidCohort StudiesFemaleHumansPostpartum PeriodPregnancyUnited StatesAnalgesics, Opioid

Identifiers

PMID36897177
PMCPMC10125002
OpenAlexW4323811404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.