Evidence map›Paper›PMID 36896967›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Effectiveness of Intermittent Screening and Treatment of Malaria in Pregnancy on Maternal and Birth Outcomes in Selected Districts in Rwanda: A Cluster Randomized Controlled Trial.

Aline Uwimana, Reena Sethi, Monique Murindahabi, Celestin Ntirandeka, Emily Piercefield, Noella Umulisa, Andrew Abram, Erin Eckert, Kaendi Munguti, David Sullivan and 3 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03508349 (Effectiveness of Intermittent Screening and Treatment of Malaria in Pregnancy), which is not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03508349 nacompletednot on this map

Effectiveness of Intermittent Screening and Treatment of Malaria in Pregnancy (ISTp) on Maternal and Birth Outcomes in Selected Districts in Rwanda

TypeinterventionalSponsorJhpiegoRan2016 to 2019Enrolled1,786ConditionsMalaria in PregnancyArmsIST
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Aline UwimanaMalaria and Other Parasitic Diseases Division, Rwanda Biomedical Center, Kigali, Rwanda.
Reena SethiMaternal and Child Survival Program-Jhpiego, Washington, District of Columbia, USA.
Monique MurindahabiMalaria and Other Parasitic Diseases Division, Rwanda Biomedical Center, Kigali, Rwanda.
Celestin NtirandekaMaternal and Child Survival Program-Jhpiego, Kigali, Rwanda.
Emily PiercefieldUS President's Malaria Initiative, Malaria Branch, US Centers for Disease Control and Prevention, USA.
Noella UmulisaMaternal and Child Survival Program-Jhpiego, Kigali, Rwanda.
Andrew AbramUS Peace Corps, Kigali, Rwanda.
Erin EckertUS PMI Impact Malaria Project, Population Services International, Washington, District of Columbia, USA.
Kaendi MungutiUS Agency for International Development, US President's Malaria Initiative, Kigali, Rwanda.
David SullivanMolecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Didier UyizeyeMalaria and Other Parasitic Diseases Division, Rwanda Biomedical Center, Kigali, Rwanda.
Aimable MbituyumuremyiMalaria and Other Parasitic Diseases Division, Rwanda Biomedical Center, Kigali, Rwanda.
Julie R GutmanMalaria Branch, Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Rwanda Biomedical Center · RWAssociation of Maternal and Child Health Programs · USCenter for Global Health · USCenters for Disease Control and Prevention · USJohns Hopkins University · USPopulation Services International · USU.S. President's Malaria Initiative · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundMalaria during pregnancy can cause serious consequences including maternal anemia and low birthweight (LBW). Routine antenatal care (ANC) in Rwanda includes malaria symptom screening at each ANC visit. This cluster randomized controlled trial investigated whether adding intermittent screening with a malaria rapid diagnostic test at each routine ANC visit and treatment of positives during pregnancy (ISTp) is more effective than routine ANC for reducing malaria prevalence at delivery.

methodsBetween September 2016 and June 2018, pregnant women initiating ANC at 14 health centers in Rwanda were enrolled into ISTp or control arms. All women received an insecticide-treated bed net at enrollment. Hemoglobin concentration, placental and peripheral parasitemia, newborn outcome, birthweight, and prematurity were assessed at delivery.

resultsNine hundred seventy-five women were enrolled in ISTp and 811 in the control group. Routine ANC plus ISTp did not significantly reduce polymerase chain reaction-confirmed placental malaria compared to control (adjusted relative risk [aRR], 0.94 [95% confidence interval {CI}, .59-1.50]; P = .799). ISTp had no impact on anemia (aRR, 1.08 [95% CI, .57-2.04]; P = .821). The mean birthweight of singleton newborns was not significantly different between arms (3054 g vs 3096 g, P = .395); however, women in the ISTp arm had a higher proportion of LBW (aRR, 1.59 [95% CI, 1.02-2.49]; P = .042).

conclusionsThis is the only study to compare ISTp to symptomatic screening at ANC in a setting where intermittent preventive treatment is not routinely provided. ISTp did not reduce the prevalence of malaria or anemia at delivery and was associated with an increased risk of LBW. CLINICAL TRIALS REGISTRATION: NCT03508349.

Indexed as

AnemiaAntimalarialsMalariaPregnancy Complications, ParasiticBirth WeightDrug CombinationsFemaleHumansInfant, NewbornPlacentaPregnancyPyrimethamineRwandaAntimalarialsDrug CombinationsPyrimethamineintermittent screeningmalariapregnancyRwanda

Identifiers

PMID36896967
PMCPMC10330390
OpenAlexW4323811831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.