ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999-2018.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetic Age Acceleration as a Modifiable Public Health Target: A Systematic Review and Meta-Analysis of Environmental, Behavioral, and Social Determinants with Development of the MEAB-Index.International journal of molecular sciences · 2026Pooled it
- Trial
- Relative impact of multidomain lifestyle interventions on deficit accumulation frailty over 24 months in the U.S. POINTER trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank.The journal of nutrition, health & aging · 2026Article
- Diet Quality, Physical Activity, and Epigenetic Aging in the Finnish Working-Age Population.The Journal of nutrition · 2026Article
- The role of dietary patterns on epigenetic and inflammatory aging based on the INSPIRE-T study.Communications medicine · 2026Article
- Association of Edentulism With Subsequent Biological Age: A Cohort Study.Journal of clinical periodontology · 2026Article
- Association of healthy lifestyle with tooth count among adults aged 20 years and above: a cross-sectional study.BMC oral health · 2026Article
- The neutrophil-percentage-to-albumin ratio (NPAR) shows a nonlinear correlation with all-cause mortality in patients with anemia.Clinical and experimental medicine · 2026Article
- Dietary rhythms and biological aging risk across multiple organs.NPJ science of food · 2026Article
- Hypertension Subtypes and Diabetes: Joint Associations in the National Health and Nutrition Examination Survey.JACC. Advances · 2026Article
- How We Sleep, How We Move, How Long We Expect to Live: An Integrative Review of Lifestyle Behaviors and Subjective Life Expectancy.Nutrients · 2026Review
- Gardening, healthy aging, and longevity: Longitudinal evidence from 25 years of the Lothian Birth Cohort 1921.Journal of environmental psychology · 2026Article
- Socioeconomic stratification in the association between tea consumption and skeletal muscle mass among oilfield workers.Frontiers in nutrition · 2026Article
- Associations of physical activity domains and delayed biological aging: assessing heterogeneity and interaction of effects.Biology of sport · 2026Article
- Integrative research on technology-assisted physical activity and biological aging: a review of wearable sensors, tele-exercise platforms, and aging biomarkers.Frontiers in medicine · 2026Review
- Article
- Patterns of Organ-Specific Proteomic Aging in Relation to Lifestyle, Diseases, and Mortality.Aging cell · 2025Article
- The association between phenotypic age acceleration and the risk of all-cause and cancer mortality among cancer survivors: NHANES 1999-2018.Scientific reports · 2025Article
- Combined association between phenotypic age acceleration and dietary fiber intake with mortality in middle-aged and elderly cancer survivors.Nutrition journal · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
People who have a balanced diet and engage in more physical activity live longer, healthier lives. This study aimed to test the hypothesis that these associations reflect a slowing of biological processes of aging. We analyzed data from 42 625 participants (aged 20-84 years, 51% female participants) from the National Health and Nutrition Examination Surveys (NHANES), 1999-2018. We calculated adherence to a Mediterranean diet (MeDi) and level of leisure time physical activity (LTPA) using standard methods. We measured biological aging by applying the PhenoAge algorithm, developed using clinical and mortality data from NHANES-III (1988-94), to clinical chemistries measured from a blood draw at the time of the survey. We tested the associations of diet and physical activity measures with biological aging, explored synergies between these health behaviors, and tested heterogeneity in their associations across strata of age, sex, and body mass index. Participants who adhered to the MeDi and who did more LTPA had younger biological ages compared with those who had less-healthy lifestyles (high vs low MeDi tertiles: β = 0.14 standard deviation [SD] [95% confidence interval {CI}: -0.18, -0.11]; high vs sedentary LTPA, β = 0.12 SD [-0.15, -0.09]), in models controlled for demographic and socioeconomic characteristics. Healthy diet and regular physical activity were independently associated with lower clinically defined biological aging, regardless of age, sex, and BMI category.
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