ArticleHuman brain mapping2023
Optic radiations representing different eccentricities age differently.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A software ecosystem for brain tractometry processing, analysis, and insight.PLoS computational biology · 2025Article
- Fiber microstructure quantile (FMQ) regression: A novel statistical approach for analyzing white matter bundles from periphery to core.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Grey matter volume and fractional anisotropy as biomarkers of cognitive change in traumatic brain injury over a 6-month period.Frontiers in neurology · 2025Article
- Sub-bundle based analysis reveals the role of human optic radiation in visual working memory.Human brain mapping · 2024Article
- Tractometry of Human Visual White Matter Pathways in Health and Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Convolutional neural network-based classification of glaucoma using optic radiation tissue properties.Communications medicine · 2024Article
- Optic radiations representing different eccentricities age differently.Human brain mapping · 2023Article
- Massively parallelized brain tractography using compute clusters, supercomputers, and graphics processing units.Imaging neuroscience (Cambridge, Mass.)Article
- Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The neural pathways that carry information from the foveal, macular, and peripheral visual fields have distinct biological properties. The optic radiations (OR) carry foveal and peripheral information from the thalamus to the primary visual cortex (V1) through adjacent but separate pathways in the white matter. Here, we perform white matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data from subjects with healthy vision in the U.K. Biobank dataset (UKBB; N = 5382; age 45-81). We use pyAFQ to characterize white matter tissue properties in parts of the OR that transmit information about the foveal, macular, and peripheral visual fields, and to characterize the changes in these tissue properties with age. We find that (1) independent of age there is higher fractional anisotropy, lower mean diffusivity, and higher mean kurtosis in the foveal and macular OR than in peripheral OR, consistent with denser, more organized nerve fiber populations in foveal/parafoveal pathways, and (2) age is associated with increased diffusivity and decreased anisotropy and kurtosis, consistent with decreased density and tissue organization with aging. However, anisotropy in foveal OR decreases faster with age than in peripheral OR, while diffusivity increases faster in peripheral OR, suggesting foveal/peri-foveal OR and peripheral OR differ in how they age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.