ArticleHuman brain mapping2023
Accumulation of network redundancy marks the early stage of Alzheimer's disease.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Alzheimer's Disease as a Multi-Layer Network Disorder: A Systems Biology Framework Integrating Multi-Omics Mechanisms.Biomedicines · 2026Review
- Claustrum and Hippocampus Segmentation-Based Alzheimer's Disease Identification Model Using RoT-Kmeans and CoLU-CNN.Molecular neurobiology · 2026Article
- Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults withNeuroimage. Reports · 2025Article
- Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement.Nature communications · 2025Article
- A group based network analysis for Alzheimer's disease fMRI data.Scientific reports · 2025Article
- Revealing excitation-inhibition imbalance in Alzheimer's disease using multiscale neural model inversion of resting-state functional MRI.Communications medicine · 2025Article
- Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.Frontiers in aging neuroscience · 2025Article
- Uncovering abnormal gray and white matter connectivity patterns in Alzheimer's disease spectrum: a dynamic graph theory analysis for early detection.Frontiers in aging neuroscience · 2025Article
- Choosing explanation over performance: Insights from machine learning-based prediction of human intelligence from brain connectivity.PNAS nexus · 2024Article
- Jointly constrained group sparse connectivity representation improves early diagnosis of Alzheimer's disease on routinely acquired T1-weighted imaging-based brain network.Health information science and systems · 2024Article
- Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle-to-old aged community participants.Human brain mapping · 2024Article
- Normalized group activations based feature extraction technique using heterogeneous data for Alzheimer's disease classification.PeerJ. Computer science · 2024Article
- Accumulation of network redundancy marks the early stage of Alzheimer's disease.Human brain mapping · 2023Article
- Triple-network analysis of Alzheimer's disease based on the energy landscape.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Brain wiring redundancy counteracts aging-related cognitive decline by reserving additional communication channels as a neuroprotective mechanism. Such a mechanism plays a potentially important role in maintaining cognitive function during the early stages of neurodegenerative disorders such as Alzheimer's disease (AD). AD is characterized by severe cognitive decline and involves a long prodromal stage of mild cognitive impairment (MCI). Since MCI subjects are at high risk of converting to AD, identifying MCI individuals is essential for early intervention. To delineate the redundancy profile during AD progression and enable better MCI diagnosis, we define a metric that reflects redundant disjoint connections between brain regions and extract redundancy features in three high-order brain networks-medial frontal, frontoparietal, and default mode networks-based on dynamic functional connectivity (dFC) captured by resting-state functional magnetic resonance imaging (rs-fMRI). We show that redundancy increases significantly from normal control (NC) to MCI individuals and decreases slightly from MCI to AD individuals. We further demonstrate that statistical features of redundancy are highly discriminative and yield state-of-the-art accuracy of up to 96.8 ± 1.0% in support vector machine (SVM) classification between NC and MCI individuals. This study provides evidence supporting the notion that redundancy serves as a crucial neuroprotective mechanism in MCI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.