Evidence map›Paper›PMID 36896751›Full record

ArticleIndian pediatrics2023

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Covid-19 - Single-Center Experience.

Poovazhagi Varadarajan, S Elilarasi, Ritchie Sharon Solomon, Seenivasan Subramani, Ramesh Subramanian, Nisha Rangabashyam, Gomathy Srividya

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in Indian pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Poovazhagi VaradarajanDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu. Correspondence to: Dr Poovazhagi Varadarajan, HOD and Professor, Department of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu. poomuthu@gmail.com.
S ElilarasiDepartment of Pediatric Pulmonology, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu.
Ritchie Sharon SolomonDepartment of Pediatric Cardiology, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu.
Seenivasan SubramaniDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu.
Ramesh SubramanianDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu.
Nisha RangabashyamDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu.
Gomathy SrividyaDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu.
Institute of Child Health · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe the clinical presentation, phenotype and outcome of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (Covid-19) from a tertiary care center in southern India.

methods257 children fulfilling the inclusion criteria of MIS-C were prospectively enrolled from June, 2020 to March, 2022.

resultsMedian (range) age at presentation was 6 year (35 day to 12 years). Presenting features were fever (98%), vomiting (75.8%), red eyes (63%), rashes (49%), pain abdomen (49%), shock (45.9%), lymphopenia (73%, thrombocytopenia (58.3%) and anemia (45%). 103 (39.7%) children required intensive care admission. Shock phenotype, Kawasaki-like phenotype and no specific phenotype were diagnosed in 45.9%, 44.4%, and 36.6% children, respectively. Left ventricular dysfunction (30.3%), acute kidney injury (13%), acute liver failure (17.4%), and hemophagolymphohistiocytosis (HLH) (13.6%) were the major system involvement in MIS-C. Mitral regurgitation (P=0.029), hyperechogenic coronaries (P=0.006), Left ventricular dysfunction (P=0.001) and low ejection fraction (P=0.007) were significantly associated with shock. Overall mortality was 11.7%.

conclusionKawasaki-like and shock-like presentation were common in MIS-C. Coronary abnormalities were seen in 118 (45.9%) children. Children with acute kidney injury, HLH, need for mechanical ventilation, and echocardiogram evidence of mitral regurgitation in MIS-C have a poor outcome.

Indexed as

COVID-19Mitral Valve InsufficiencyVentricular Dysfunction, LeftHumansSARS-CoV-2Systemic Inflammatory Response Syndrome

Identifiers

PMID36896751
PMCPMC10185933
OpenAlexW4323805016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.