Evidence map›Paper›PMID 36896750›Full record

ArticleIndian pediatrics2023

Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics - A Single-Center Experience From a Tropical Setting.

S Balasubramanian, Janani Sankar, K Dhanalakshmi, S Lakshan Raj, Divya Nandakumar, A V Ramanan, Sara Chandy

Open access · bronzeAbstract read
In one paragraph

Article in Indian pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. MIS-C: Diagnosis, Management, and Outcomes.Open forum infectious diseases · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

S BalasubramanianDepartment of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.
Janani SankarDepartment of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.
K DhanalakshmiDepartment of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.
S Lakshan RajDepartment of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India. Correspondence to: Dr S Lakshan Raj, Department of Paediatrics, KanchiKamakoti CHILDS Trust Hospital, 12A Nageswara Road, Nungambakkam, Chennai, Tamil Nadu 600 034. doc.lakshanraj2311@gmail.com.
Divya NandakumarDepartment of Paediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.
A V RamananBristol Royal Hospital for Children, Bristol, United Kingdom.
Sara ChandyMolecular Laboratory, The CHILDS Trust Medical Research Foundation, Chennai, Tamil Nadu, India.
Kanchi Kamakoti CHILDS Trust Hospital · INBristol Royal Hospital for Children · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIdentifying clinical and laboratory indicators that differentiate multisystem inflam-matory syndrome in children (MIS-C) apart from other febrile diseases in a tropical hospital setting.

methodsReview of hospital records done in a tertiary care exclusive children's hospital for children admitted from April, 2020 till June, 2021. Laboratory values, severe acute respiratory syndrome coronavirus (SARS-CoV-2) serological status, and clinical signs and symptoms of patients with MIS-C, and those with similar presentations were analyzed.

results114 children fulfilled the inclusion criteria (age group of 1 mo-18 y) for whom a diagnosis of MIS-C was considered in the emergency room based on the clinical features. Among them, 64 children had the final diagnosis of MIS-C, and the remaining 50 children had confirmatory evidence of infections mimicking MIS-C such as enteric fever, scrub typhus, dengue and appendicitis.

conclusionOlder age group, presence of muco-cutaneous symptoms, very high C-reactive protein, neutrophilic leukocytosis, abdominal pain and absence of hepatosplenomegaly favor a diagnosis of MIS-C.

Indexed as

COVID-19AgedChildHospitalizationHumansInfantSARS-CoV-2Systemic Inflammatory Response Syndrome

Identifiers

PMID36896750
PMCPMC10185926
OpenAlexW4323812857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.