Evidence map›Paper›PMID 36896582›Full record

ArticleChemical communications (Cambridge, England)2023

Competitive aminal formation during the synthesis of a highly soluble, isopropyl-decorated imine porous organic cage.

Rachel J Kearsey, Andrew Tarzia, Marc A Little, Michael C Brand, Rob Clowes, Kim E Jelfs, Andrew I Cooper, Rebecca L Greenaway

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In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel J KearseyDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool, L7 3NY, UK. aicooper@liverpool.ac.uk.
Andrew TarziaDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. r.greenaway@imperial.ac.uk.ORCID http://orcid.org/0000-0001-8797-8666
Marc A LittleDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool, L7 3NY, UK. aicooper@liverpool.ac.uk.
Michael C BrandDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool, L7 3NY, UK. aicooper@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-4556-5609
Rob ClowesDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool, L7 3NY, UK. aicooper@liverpool.ac.uk.
Kim E JelfsDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. r.greenaway@imperial.ac.uk.ORCID http://orcid.org/0000-0001-7683-7630
Andrew I CooperDepartment of Chemistry and Materials Innovation Factory, University of Liverpool, 51 Oxford Street, Liverpool, L7 3NY, UK. aicooper@liverpool.ac.uk.ORCID http://orcid.org/0000-0003-0201-1021
Rebecca L GreenawayDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK. r.greenaway@imperial.ac.uk.ORCID http://orcid.org/0000-0003-1541-4399

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of a new porous organic cage decorated with isopropyl moieties (CC21) was achieved from the reaction of triformylbenzene and an isopropyl functionalised diamine. Unlike structurally analogous porous organic cages, its synthesis proved challenging due to competitive aminal formation, rationalised using control experiments and computational modelling. The use of an additional amine was found to increase conversion to the desired cage.

Identifiers

PMID36896582
PMCPMC10035065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.