Evidence map›Paper›PMID 36896415›Full record

ArticleMaterials today. Bio2023

Precise manipulation of circadian clock using MnO

Yu-Xiang Ge, Hong-Jun Zhuang, Tai-Wei Zhang, Hai-Feng Liang, Wang Ding, Lei Zhou, Zhi-Rui Dong, Zhi-Chao Hu, Qing Chen, Jian Dong and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yu-Xiang GeDepartment of Orthopedics Surgery, Minhang Hospital, Fudan University, Shanghai 201100, China.
Hong-Jun ZhuangDepartment of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Tai-Wei ZhangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hai-Feng LiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wang DingDepartment of Orthopedics Surgery, Minhang Hospital, Fudan University, Shanghai 201100, China.
Lei ZhouDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhi-Rui DongDepartment of Orthopedics Surgery, Jinshan Hospital, Fudan University, Shanghai 201512, China.
Zhi-Chao HuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Qing ChenDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jian DongDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Li-Bo JiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xiao-Fan YinDepartment of Orthopedics Surgery, Minhang Hospital, Fudan University, Shanghai 201100, China.
Sun Yat-sen University · CNFudan University · CNJinshan Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythm (CR) disruption contributes to tumor initiation and progression, however the pharmacological targeting of circadian regulators reversely inhibits tumor growth. Precisely controlling CR in tumor cells is urgently required to investigate the exact role of CR interruption in tumor therapy. Herein, based on KL001, a small molecule that specifically interacts with the clock gene cryptochrome (CRY) functioning at disruption of CR, we fabricated a hollow MnO

Indexed as

Circadian clockHypoxiaMnO2 nanocapsulesOsteosarcomaPhotodynamic therapy

Identifiers

PMID36896415
PMCPMC9988696
OpenAlexW4318159224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.