Evidence map›Paper›PMID 36896301›Full record

ArticleWorld journal of gastrointestinal surgery2023

Does size matter for resection of giant versus non-giant hepatocellular carcinoma? A meta-analysis.

Aaron Jl Lee, Andrew Gr Wu, Kuo Chao Yew, Vishal G Shelat

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Article in World journal of gastrointestinal surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron Jl LeeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. alee047@e.ntu.edu.sg.
Andrew Gr WuYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Kuo Chao YewDepartment of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore 308433, Singapore.
Vishal G ShelatDepartment of Hepato-Pancreatico-Biliary Surgery, Tan Tok Seng Hospital, Singapore 308433, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch on long-term survival after resection of giant (≥ 10 cm) and non-giant hepatocellular carcinoma (HCC) (< 10 cm) has produced conflicting results.

aimThis study aimed to investigate whether oncological outcomes and safety profiles of resection differ between giant and non-giant HCC.

methodsPubMed, MEDLINE, EMBASE, and Cochrane databases were searched. Studies designed to investigate the outcomes of giant

results24 retrospective cohort studies involving 23747 patients (giant = 3326; non-giant = 20421) who underwent HCC resection were included. OS was reported in 24 studies, DFS in 17 studies, 30-d mortality rate in 18 studies, postoperative complications in 15 studies, and post-hepatectomy liver failure (PHLF) in six studies. The HR was significantly lower for non-giant HCC in both OS (HR 0.53, 95%CI: 0.50-0.55,

conclusionResection of giant HCC is associated with poorer long-term outcomes. The safety profile of resection was similar in both groups; however, this may have been confounded by reporting bias. HCC staging systems should account for the size differences.

Indexed as

Giant hepatocellular carcinomaHepatectomyMeta-analysisResection

Identifiers

PMID36896301
PMCPMC9988639

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