Evidence map›Paper›PMID 36896221›Full record

ArticleCardiology research2023

Is T-Wave Alternans a Repolarization Abnormality Marker in COVID-19? An Investigation on the Potentialities of Portable Electrocardiogram Device.

Alexander Edo Tondas, Dian Andina Munawar, Ilaria Marcantoni, Iche Andriyani Liberty, Rido Mulawarman, Muhammad Hadi, Monica Trifitriana, Taufik Indrajaya, Muhammad Yamin, Irfannuddin Irfannuddin and 1 more

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Article in Cardiology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Alexander Edo TondasDepartment of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia.ORCID https://orcid.org/0000-0002-2317-5212
Dian Andina MunawarDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-9273-8832
Ilaria MarcantoniDepartment of Information Engineering, Universita Politecnica delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0002-8053-3530
Iche Andriyani LibertyFaculty of Medicine, Universitas Sriwijaya Palembang, Indonesia.ORCID https://orcid.org/0000-0001-7697-6593
Rido MulawarmanFaculty of Medicine, Universitas Sriwijaya Palembang, Indonesia.ORCID https://orcid.org/0000-0003-2169-0971
Muhammad HadiFaculty of Medicine, Universitas Sriwijaya Palembang, Indonesia.ORCID https://orcid.org/0000-0002-0600-7305
Monica TrifitrianaFaculty of Medicine, Universitas Sriwijaya Palembang, Indonesia.ORCID https://orcid.org/0000-0002-9454-1961
Taufik IndrajayaCardiovascular Division, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia.
Muhammad YaminCardiovascular Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0003-0786-3856
Irfannuddin IrfannuddinFaculty of Medicine, Universitas Sriwijaya Palembang, Indonesia.ORCID https://orcid.org/0000-0002-2217-367X
Laura BurattiniDepartment of Information Engineering, Universita Politecnica delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0002-9474-7046
Sriwijaya University · IDMarche Polytechnic University · ITLyell McEwin Hospital · AUUniversity of Indonesia · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiac arrhythmias are significantly associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients. Microvolt T-wave alternans (TWA) can be automatically quantified and has been recognized as a representation of repolarization heterogeneity and linked to arrhythmogenesis in various cardiovascular diseases. This study aimed to explore the correlation between microvolt TWA and COVID-19 pathology. Methods: Patients suspected of COVID-19 in Mohammad Hoesin General Hospital were consecutively evaluated using Alivecor Results: A total of 175 patients, 114 COVID-19 patients (polymerase chain reaction (PCR)-positive group), and 61 non-COVID-19 patients (PCR-negative group) were enrolled in the study. PCR-positive group was subdivided according to the severity of COVID-19 pathology into mild and moderate severity subgroups. Baseline TWA levels were similar between both groups during admission (42.47 ± 26.52 µV vs. 44.72 ± 38.21 µV), but higher TWA levels were observed during discharge in the PCR-positive compared to the PCR-negative group (53.45 ± 34.42 µV vs. 25.15 ± 17.64 µV, P = 0.03). The correlation between PCR-positive result in COVID-19 and TWA value was significant, after adjustment of other confounding variables (R Conclusions: Higher TWA values can be observed on follow-up ECG obtained during discharge in the PCR-positive COVID-19 patients.

Indexed as

Cardiac repolarizationCOVID-19ECG deviceT-wave alternans

Identifiers

PMID36896221
PMCPMC9990541
OpenAlexW4322012337

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.