Evidence map›Paper›PMID 36896128›Full record

ArticlePNAS nexus2023

The circadian control of tryptophan metabolism regulates the host response to pulmonary fungal infections.

Claudia Stincardini, Marilena Pariano, Fiorella D'Onofrio, Giorgia Renga, Elena Orecchini, Ciriana Orabona, Emilia Nunzi, Marco Gargaro, Francesca Fallarino, Sung Kook Chun and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Circadian metabolic adaptations to infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Claudia StincardiniDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID https://orcid.org/0000-0003-4432-1562
Marilena ParianoDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Fiorella D'OnofrioDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Giorgia RengaDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Elena OrecchiniDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Ciriana OrabonaDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID https://orcid.org/0000-0003-3113-0572
Emilia NunziDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Marco GargaroDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Francesca FallarinoDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Sung Kook ChunDepartment of Biological Chemistry, University of California, Irvine (UCI), Irvine, CA 92697, USA.
Bridget M FortinDepartment of Biological Chemistry, University of California, Irvine (UCI), Irvine, CA 92697, USA.
Selma MasriDepartment of Biological Chemistry, University of California, Irvine (UCI), Irvine, CA 92697, USA.
Stefano BrancorsiniDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.ORCID https://orcid.org/0000-0002-8410-7248
Luigina RomaniDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Claudio CostantiniDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
Marina Maria BelletDepartment of Medicine and Surgery, University of Perugia, P.le L. Severi 1, 06132 Perugia, Italy.
University of Perugia · ITUniversity of California, Irvine · US

Funding

CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Circadian Clock and Myc-dependent Regulation of Cellular TransformationR01CA259370 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Selma Masri · 2022 to 2026
$3.0M
Circadian Clock Disruption and Colorectal CancerR01CA244519 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Selma Masri · 2020 to 2026
$3.0M
NCI NIH HHS R01 CA244519NCI NIH HHS R01 CA259370NCI NIH HHS T32 CA009054
6 · The paper itself

Abstract

The environmental light/dark cycle has left its mark on the body's physiological functions to condition not only our inner biology, but also the interaction with external cues. In this scenario, the circadian regulation of the immune response has emerged as a critical factor in defining the host-pathogen interaction and the identification of the underlying circuitry represents a prerequisite for the development of circadian-based therapeutic strategies. The possibility to track down the circadian regulation of the immune response to a metabolic pathway would represent a unique opportunity in this direction. Herein, we show that the metabolism of the essential amino acid tryptophan, involved in the regulation of fundamental processes in mammals, is regulated in a circadian manner in both murine and human cells and in mouse tissues. By resorting to a murine model of pulmonary infection with the opportunistic fungus

Indexed as

Aspergillus fumigatuscircadian rhythmcystic fibrosisIDO1kynurenines

Identifiers

PMID36896128
PMCPMC9991457
OpenAlexW4319159785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.