Evidence map›Paper›PMID 36895984›Full record

ArticleAmerican journal of cancer research2023

Protective role of mineralocorticoid receptor signaling in urothelial tumorigenesis.

Yujiro Nagata, Takuo Matsukawa, Takuro Goto, Yuki Teramoto, Guiyang Jiang, Naohiro Fujimoto, Hiroshi Miyamoto

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yujiro NagataDepartment of Pathology & Laboratory Medicine, University of Rochester Medical Center Rochester, NY 14642, USA.
Takuo MatsukawaDepartment of Urology, University of Occupational and Environmental Health School of Medicine Kitakyushu, Japan.
Takuro GotoDepartment of Pathology & Laboratory Medicine, University of Rochester Medical Center Rochester, NY 14642, USA.
Yuki TeramotoDepartment of Pathology & Laboratory Medicine, University of Rochester Medical Center Rochester, NY 14642, USA.
Guiyang JiangDepartment of Pathology & Laboratory Medicine, University of Rochester Medical Center Rochester, NY 14642, USA.
Naohiro FujimotoDepartment of Urology, University of Occupational and Environmental Health School of Medicine Kitakyushu, Japan.
Hiroshi MiyamotoDepartment of Pathology & Laboratory Medicine, University of Rochester Medical Center Rochester, NY 14642, USA.
University of Occupational and Environmental Health Japan · JPUniversity of Rochester Medical Center · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression status of mineralocorticoid receptor (MR) and its biological significance in human urothelial carcinoma remain unknown. The present study aimed to determine the functional role of MR in the development of urothelial cancer. In human normal urothelial SVHUC cells with exposure to a chemical carcinogen 3-methylcholanthrene (MCA), we assessed the effects of a natural MR ligand, aldosterone, and 3 MR antagonists, including spironolactone, eplerenone, and esaxerenone, as well as knockdown of MR via shRNA virus infection, on their neoplastic/malignant transformation. The

Indexed as

Aldosteroneanti-mineralocorticoidbladder cancereplerenoneesaxerenonemineralocorticoid receptorneoplastic transformationspironolactoneurothelial carcinoma

Identifiers

PMID36895984
PMCPMC9989624
OpenAlexW4323804676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.