Evidence map›Paper›PMID 36895820›Full record

ArticleNeurotrauma reports2023

Time-Dependent Changes in the Biofluid Levels of Neural Injury Markers in Severe Traumatic Brain Injury Patients-Cerebrospinal Fluid and Cerebral Microdialysates: A Longitudinal Prospective Pilot Study.

I-Hsuan Lin, Alaa Kamnaksh, Roxanne Aniceto, Jesse McCullough, Ramsey Bekdash, Michael Eklund, Per Hamid Ghatan, Mårten Risling, Mikael Svensson, Bo-Michael Bellander and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The S100B Protein: A Multifaceted Pathogenic Factor More Than a Biomarker.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

I-Hsuan LinDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Alaa KamnakshDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Roxanne AnicetoDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Jesse McCulloughDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Ramsey BekdashDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Michael EklundDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Per Hamid GhatanDepartment of Neuroscience, Uppsala University Hospital, Uppsala, Sweden.
Mårten RislingDepartment of Neuroscience, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Mikael SvenssonDepartment of Clinical Neuroscience, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Bo-Michael BellanderDepartment of Clinical Neuroscience, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
David W NelsonDepartment of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
Eric Peter ThelinDepartment of Clinical Neuroscience, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Denes V AgostonDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, Maryland, USA.
Uniformed Services University of the Health Sciences · USKarolinska University Hospital · SEUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring protein biomarker levels in the cerebrospinal fluid (CSF) can help assess injury severity and outcome after traumatic brain injury (TBI). Determining injury-induced changes in the proteome of brain extracellular fluid (bECF) can more closely reflect changes in the brain parenchyma, but bECF is not routinely available. The aim of this pilot study was to compare time-dependent changes of S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), total Tau, and phosphorylated Tau (p-Tau) levels in matching CSF and bECF samples collected at 1, 3, and 5 days post-injury from severe TBI patients (

Indexed as

biomarkercMDCSFproteintemporaltraumatic brain injury

Identifiers

PMID36895820
PMCPMC9989523
OpenAlexW4322724924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.