Evidence map›Paper›PMID 36895798›Full record

ArticleFrontiers in neural circuits2023

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.

Alicia N Vagnozzi, Matthew T Moore, Raquel López de Boer, Aambar Agarwal, Niccolò Zampieri, Lynn T Landmesser, Polyxeni Philippidou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alicia N VagnozziDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States.
Matthew T MooreDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States.
Raquel López de BoerDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States.
Aambar AgarwalDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States.
Niccolò ZampieriMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Lynn T LandmesserDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States.
Polyxeni PhilippidouDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · USMax Delbrück Center · DE

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Genetic Control of Respiratory Motor Circuit Development, Connectivity and MaintenanceR01NS114510 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Polyxeni Philippidou · 2020 to 2026
$3.0M
Molecular Mechanisms of Phrenic Motor Neuron DevelopmentF30HD096788 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI VAGNOZZI, ALICIA NICOLE · 2018 to 2021
$201k
Molecular Mechanisms of Respiratory Circuit ConnectivityF31NS124240 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MOORE, MATTHEW THOMAS · 2022 to 2024
$91k
NICHD NIH HHS F30 HD096788NIGMS NIH HHS T32 GM007250NINDS NIH HHS F31 NS124240NINDS NIH HHS R01 NS114510
6 · The paper itself

Abstract

Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival. Despite their critical role, the mechanisms that control phrenic MN development and function are not well understood. Here, we show that catenin-mediated cadherin adhesive function is required for multiple aspects of phrenic MN development. Deletion of β- and γ-

Indexed as

CateninsMotor NeuronsAxonsDiaphragmFemaleHumansPregnancySignal TransductionCateninsbreathingcadherinscateninsphrenic motor neuronsrespiratory

Identifiers

PMID36895798
PMCPMC9988953
OpenAlexW4321459143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.