ReviewiScience2023
Safety by design: Biosafety and biosecurity in the age of synthetic genomics.
Review in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Genomic Impacts of Biological Exposures.Journal of developmental biology · 2026Review
- Towards the development of a CRISPR-Cas9 based kill switch for Saccharomyces cerevisiae.Microbial cell factories · 2026Article
- CRISPR-GPT for agentic automation of gene-editing experiments.Nature biomedical engineering · 2026Article
- High-throughput yeast engineering in biofoundries: towards autonomous and scalable synthetic biology.FEMS yeast research · 2026Review
- Red-teaming as an imperative for strengthening synthetic nucleic acid screening.Frontiers in bioengineering and biotechnology · 2026Review
- Plant resistance: scientific basis and latest research progress.Frontiers in plant science · 2026Review
- Know your scientist: KYC as biosecurity infrastructure.Frontiers in microbiology · 2026Article
- Developing a standard definition for sequences of concern.Frontiers in bioengineering and biotechnology · 2026Article
- Governing synthetic biology and artificial intelligence (AI) convergence: emerging biosecurity priorities for Africa.Frontiers in bioengineering and biotechnology · 2026Review
- A national framework for managing dual-use research of concern: integrating biosecurity, public health, and research governance.Frontiers in bioengineering and biotechnology · 2026Article
- The microbial strategies for the management of chemical pesticides: A comprehensive review.Current research in microbial sciences · 2026Review
- Article
- The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025Review
- Emerging trends in genome integration tools for precision engineering of diverse bacterial species.Synthetic biology (Oxford, England) · 2025Review
- Diagnosing and engineering gut microbiomes.EMBO molecular medicine · 2024Review
- Progress and Prospects for a Nucleic Acid Screening Test Set.Applied biosafety : journal of the American Biological Safety Association · 2024Article
- Five Things Not to Do When Discovering a Biosecurity Vulnerability.Applied biosafety : journal of the American Biological Safety Association · 2024Article
- A Sensitivity Study for Interpreting Nucleic Acid Sequence Screening Regulatory and Guidance Documentation: Toward a Foundational Synthetic Nucleic Acid Sequence Screening Framework.Applied biosafety : journal of the American Biological Safety Association · 2024Article
- Practical Questions for Securing Nucleic Acid Synthesis.Applied biosafety : journal of the American Biological Safety Association · 2024Article
- Annotation of Functions of Sequences of Concern and Its Relevance to the New Biosecurity Regulatory Framework in the United States.Applied biosafety : journal of the American Biological Safety Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Technologies to profoundly engineer biology are becoming increasingly affordable, powerful, and accessible to a widening group of actors. While offering tremendous potential to fuel biological research and the bioeconomy, this development also increases the risk of inadvertent or deliberate creation and dissemination of pathogens. Effective regulatory and technological frameworks need to be developed and deployed to manage these emerging biosafety and biosecurity risks. Here, we review digital and biological approaches of a range of technology readiness levels suited to address these challenges. Digital sequence screening technologies already are used to control access to synthetic DNA of concern. We examine the current state of the art of sequence screening, challenges and future directions, and environmental surveillance for the presence of engineered organisms. As biosafety layer on the organism level, we discuss genetic biocontainment systems that can be used to created host organisms with an intrinsic barrier against unchecked environmental proliferation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.