ReviewThe Lancet regional health. Europe2023
Dementia prevention in memory clinics: recommendations from the European task force for brain health services.
4 registry-linked trialsAbstract readReview
In one paragraph
Review in The Lancet regional health. Europe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 112 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07284316 phase2 / phase3active not recruitingnot on this mapstarted 2025, after this paper: background citation
Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance: A Randomized Clinical Trial
Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults - the LETHE-AT Randomised-controlled, Multicentre Pilot Trial
Preliminary Assessment of the Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Intervention Supported by a Website to Prevent Cognitive Decline in Older Adults
Evaluation of the Long-Term Cognitive, Biological, and Lifestyle Effects of a Multimodal Intervention for Preventing Cognitive Decline in APOE-ε4 Carriers With Subjective Cognitive Decline
Who cites it
112 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for primary care.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Guideline
- Association between periodontal disease and Alzheimer's disease: umbrella review.Frontiers in dental medicine · 2025Pooled it
- [PAPPS update on older people 2024].Atencion primaria · 2024Guideline
- Human Leukocyte Antigen and microRNAs as Key Orchestrators of Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline.European geriatric medicine · 2023Guideline
- Reducing fear and avoidance of memory loss improves mood and social engagement in community-based older adults: a randomized trial.BMC geriatrics · 2023Trial
- Dementia risk factors and biomarkers in subjective cognitive decline: real world evidence from the monza brain health service.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- From memory clinics to Brain Health Services: implications for older adults and the future of cognitive care in Europe.European geriatric medicine · 2026Article
- Brain health awareness among solid organ transplant candidates and recipients: a single centre survey.BMC neurology · 2026Article
- Detecting amyloid-β pathology in subjective cognitive decline using plasma and CSF biomarkers.EBioMedicine · 2026Article
- Just Semantics? How Diagnostic Criteria Influence Physician-Patient Narratives in Alzheimer's Disease.Neuro-degenerative diseases · 2026Article
- Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adults.medRxiv : the preprint server for health sciences · 2026Article
- Defining Alzheimer's disease: stipulations and the ethics of diagnostic change.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Dementia risk factor assessment in a local Alzheimer's prevention population: a German cross-sectional, observational study.The journal of prevention of Alzheimer's disease · 2026Observational
- Hyperglycemia impairs cognitive function by inducing mitochondrial damage through lactylation of LRPPRC at K223.EMBO molecular medicine · 2026Article
- Towards specialized dementia risk reduction services for those with first cognitive symptoms: A mixed-method study into risk awareness, needs, and preferences among individuals with subjective cognitive decline and mild cognitive impairment from memory clinic and community settings and memory clinic professionals.Journal of Alzheimer's disease : JAD · 2026Article
- The presymptomatic and early manifestations of semantic dementia.Brain : a journal of neurology · 2026Article
- Minor neuropsychological deficits and stage 2 of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Application of Deep Multi-Scale Representation Learning Based on Eye-Tracking and Facial Expression Data in Cognitive Decline Assessment.Sensors (Basel, Switzerland) · 2026Article
- The best treatment is prevention: prevention of cognitive decline and dementia - current state, gaps and next steps.Neurological research and practice · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors.
Giovanni B FrisoniMemory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland.
Daniele AltomareMemory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland.
Federica RibaldiMemory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland.
Nicolas VillainInstitut de la Mémoire et de la Maladie d'Alzheimer, IM2A, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Paris, France.
Carol BrayneCambridge Public Health, University of Cambridge, Cambridge, UK.
Naaheed MukadamDivision of Psychiatry, University College London, London, UK.
Marc AbramowiczGenetic Medicine, Diagnostics Dept, University Hospitals and University of Geneva, Geneva, Switzerland.
Frederik BarkhofRadiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Marcelo BerthierUnit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Malaga, Malaga, Spain.
Melanie Bieler-AeschlimannLeenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Kaj BlennowClinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.
Andrea Brioschi GuevaraLeenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Emmanuel CarreraStroke Center, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland.
Gaël ChételatNormandie University, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France.
Chantal CsajkaCenter of Research and Innovation in Clinical Pharmaceutical Sciences, University Hospital and University of Lausanne, Lausanne, Switzerland.
Jean-François DemonetLeenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Alessandra DodichCenter for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy.
Valentina GaribottoDivision of Nuclear Medicine and Molecular Imaging, University Hospitals of Geneva and NIMTLab, University of Geneva, Geneva, Switzerland.
Jean GeorgesAlzheimer Europe, Luxembourg.
Samia HurstInstitute for Ethics, History, and the Humanities, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Frank JessenDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
David J LlewellynCollege of Medicine and Health, University of Exeter, UK.
Laura McWhirterCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
Richard MilneCambridge Public Health, University of Cambridge, Cambridge, UK.
Carolina MinguillónBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Carlo MiniussiCenter for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy.
José Luis MolinuevoBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Peter M NilssonDepartment of Clinical Science, Lund University, Sweden.
Alastair NoycePreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Janice M RansonCollege of Medicine and Health, University of Exeter, UK.
Oriol Grau-RiveraBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Alina SolomonInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Ruth StephenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Wiesje van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands.
Cornelia van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Bruno VellasGerontopole and Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France.
Leonie N C VisserDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Jeffrey L CummingsChambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV, USA.
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands.
Craig RitchieCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Bruno DuboisInstitut de la Mémoire et de la Maladie d'Alzheimer, IM2A, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Paris, France.
Funding
Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's DiseaseR01AG053798 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AISEN, PAUL S., CUMMINGS, JEFFREY L. · 2017 to 2022
$39.4MRenewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI Robert J. Fox, Jefferson Kinney · 2015 to 2026
$22.8MNVEDARC Clinical CoreP20AG068053 · NIA · CLEVELAND CLINIC FOUNDATION · PI FOX, ROBERT J. · 2020 to 2022
$3.3MAlzheimer's Clinical Trial InnOvatioN (ACTION) InitiativeR35AG071476 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI CUMMINGS, JEFFREY L. · 2021 to 2025
$2.9MMedical Research Council G0601022Medical Research Council G9901400NIA NIH HHS P20 AG068053NIA NIH HHS R35 AG071476NIGMS NIH HHS P20 GM109025
Abstract
Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.
Indexed as
Cognitive enhancementDementiaMemory clinicPreventionRisk assessmentRisk communicationRisk reduction
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT07284316ClinicalTrials.gov
NCT07376135ClinicalTrials.gov
NCT07668440ClinicalTrials.gov
NCT07730671ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.