Evidence map›Paper›PMID 36895414›Full record

ArticleJournal of biomedical optics2023

Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies.

Weylan R Thompson, Hans-Peter F Brecht, Vassili Ivanov, Anthony M Yu, Diego S Dumani, Dylan J Lawrence, Stanislav Y Emelianov, Sergey A Ermilov

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  8. Bornite (CuPhotoacoustics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Weylan R ThompsonPhotoSound Technologies, Inc., Houston, Texas, United States.ORCID 0000-0002-0193-2649
Hans-Peter F BrechtPhotoSound Technologies, Inc., Houston, Texas, United States.
Vassili IvanovPhotoSound Technologies, Inc., Houston, Texas, United States.
Anthony M YuGeorgia Institute of Technology, Department of Biomedical Engineering, Atlanta, Georgia, United States.ORCID 0000-0002-4830-6346
Diego S DumaniGeorgia Institute of Technology, Department of Biomedical Engineering, Atlanta, Georgia, United States.ORCID 0000-0002-0086-4250
Dylan J LawrencePhotoSound Technologies, Inc., Houston, Texas, United States.ORCID 0000-0001-9483-6156
Stanislav Y EmelianovGeorgia Institute of Technology, Department of Biomedical Engineering, Atlanta, Georgia, United States.ORCID 0000-0002-7098-133X
Sergey A ErmilovPhotoSound Technologies, Inc., Houston, Texas, United States.ORCID 0000-0001-9041-9996
Georgia Institute of Technology · US

Funding

Integrated photoacoustic and fluorescence imaging system for anatomical, functional, and molecular characterization of murine modelsR44OD023029 · OD · PHOTOSOUND TECHNOLOGIES, INC. · PI BRECHT, HANS-PETER FRANZ · 2022 to 2023
$1.9M
Preclinical small animal imaging platform for detection and quantification of early metastasisR43CA224824 · NCI · PHOTOSOUND TECHNOLOGIES, INC. · PI ERMILOV, SERGEY A · 2018 to 2019
$334k
Integrated photoacoustic and fluorescence imaging system for anatomical, functional, and molecular characterization of murine modelsR43OD023029 · OD · PHOTOSOUND TECHNOLOGIES, INC. · PI ERMILOV, SERGEY A · 2017 to 2017
$211k
NCI NIH HHS R43 CA224824NIH HHS R43 OD023029NIH HHS R44 OD023029
6 · The paper itself

Abstract

Significance: To effectively study preclinical animal models, medical imaging technology must be developed with a high enough resolution and sensitivity to perform anatomical, functional, and molecular assessments. Photoacoustic (PA) tomography provides high resolution and specificity, and fluorescence (FL) molecular tomography provides high sensitivity; the combination of these imaging modes will enable a wide range of research applications to be studied in small animals. Aim: We introduce and characterize a dual-modality PA and FL imaging platform using Approach: The imaging platform's detection limits were characterized through phantom studies that determined the PA spatial resolution, PA sensitivity, optical spatial resolution, and FL sensitivity. Results: The system characterization yielded a PA spatial resolution of Conclusions: The combined PA and FL imaging system has been characterized and has demonstrated its ability to image mice

Indexed as

Optical ImagingPhotoacoustic TechniquesAnimalsMicePhantoms, ImagingSpectrum AnalysisTomographyTomography, X-Ray Computedfluorescencemedical imagingmousephotoacoustictomography

Identifiers

PMID36895414
PMCPMC9990133
OpenAlexW4323355002

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.